Chemistry:Propofol hemisuccinate
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| Formula | C16H22O4 |
| Molar mass | 278.348 g·mol−1 |
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Propofol hemisuccinate, is an anesthetic drug which is an ester substituted prodrug of propofol. Propofol itself is a viscous, oily liquid which does not dissolve in water and has to be formulated as an oil-in-water emulsion. Propofol hemisuccinate is a modified form of propofol which can be made into a water-soluble salt, and can be administered by routes such as by inhalation which are impossible with the unmodified propofol parent compound. It has improved neuroprotective properties compared to propofol.[1][2][3]
See also
- Cipepofol
- Etomidate
- Fospropofol
- Oxazepam hemisuccinate
References
- ↑ "Propofol hemisuccinate protects neuronal cells from oxidative injury". Journal of Neurochemistry 73 (6): 2524–2530. December 1999. doi:10.1046/j.1471-4159.1999.0732524.x. PMID 10582614.
- ↑ "Propofol hemisuccinate suppression of experimental autoimmune encephalomyelitis". Autoimmunity 40 (3): 180–186. May 2007. doi:10.1080/08916930701204467. PMID 17453716.
- ↑ "Seizure protection by intrapulmonary delivery of propofol hemisuccinate". The Journal of Pharmacology and Experimental Therapeutics 336 (1): 215–222. January 2011. doi:10.1124/jpet.110.173591. PMID 20837991.
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