Chemistry:Suprofen
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Short description: Non-steroidal anti-inflammatory drug
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Routes of administration | Oral, eye drops |
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Protein binding | 20% |
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Formula | C14H12O3S |
Molar mass | 260.31 g·mol−1 |
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Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica[1] that was marketed as 1% eye drops under the trade name Profenal.
Uses
Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.[3] This application has been discontinued as well, at least in the US.[4]
References
- ↑ Janssen PA, Van Daele GH, Boey JM, "Antiphlogistic aroyl-substituted phenylacetic acid derivatives", DE patent 2353357, issued 1974
- ↑ "Renal Effects of Nonsteroidal Anti-Inflammatory Drugs". Basis for Variability of Response to Anti-Rheumatic Drugs. 24. 1988. 95–106. doi:10.1007/978-3-0348-9160-8_9. ISBN 978-3-0348-9931-4.
- ↑ "Pharmacy Compounding". Guidance for FDA Staff and Industry Compliance Policy Guides Manual. U.S. Food and Drug Administration. https://www.fda.gov/ora/compliance_ref/cpg/cpgdrg/cpg460-200.html.
- ↑ "Suprofen ophthalmic". Drugs.com. https://www.drugs.com/mtm/suprofen-ophthalmic.html.
Original source: https://en.wikipedia.org/wiki/Suprofen.
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