Chemistry:Suprofen

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Short description: Non-steroidal anti-inflammatory drug
Suprofen
Suprofen.svg
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Oral, eye drops
ATC code
Legal status
Legal status
  • Discontinued
Pharmacokinetic data
Protein binding20%
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC14H12O3S
Molar mass260.31 g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica[1] that was marketed as 1% eye drops under the trade name Profenal.

Uses

Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.[3] This application has been discontinued as well, at least in the US.[4]

References

  1. Janssen PA, Van Daele GH, Boey JM, "Antiphlogistic aroyl-substituted phenylacetic acid derivatives", DE patent 2353357, issued 1974
  2. "Renal Effects of Nonsteroidal Anti-Inflammatory Drugs". Basis for Variability of Response to Anti-Rheumatic Drugs. 24. 1988. 95–106. doi:10.1007/978-3-0348-9160-8_9. ISBN 978-3-0348-9931-4. 
  3. "Pharmacy Compounding". Guidance for FDA Staff and Industry Compliance Policy Guides Manual. U.S. Food and Drug Administration. https://www.fda.gov/ora/compliance_ref/cpg/cpgdrg/cpg460-200.html. 
  4. "Suprofen ophthalmic". Drugs.com. https://www.drugs.com/mtm/suprofen-ophthalmic.html.