Chemistry:Alprazolam triazolobenzophenone
From HandWiki
Short description: Chemical compound
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| Formula | C17H15ClN4O |
| Molar mass | 326.8 g·mol−1 |
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Alprazolam triazolobenzophenone is a chemical compound which can be both a synthetic precursor and a prodrug for the benzodiazepine derivative alprazolam. At neutral pH it readily cyclizes to alprazolam, while in acidic conditions alprazolam undergoes a ring-opening reaction back to the triazolobenzophenone. A series of related acyl derivatives was researched in the 1980s as injectable water-soluble prodrugs of alprazolam,[1] but were never developed for medical use. Subsequently, this compound has been detected as a designer drug, first being identified from a seizure in Spain in March 2014.[2]
See also
References
- ↑ "Sequentially labile water-soluble prodrugs of alprazolam". Journal of Medicinal Chemistry 29 (8): 1346–50. August 1986. doi:10.1021/jm00158a004. PMID 3016261.
- ↑ "Novel Benzodiazepines. A review of the evidence of use and harms of Novel Benzodiazepines.". Advisory Council on the Misuse of Drugs. April 2020. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/881969/ACMD_report_-_a_review_of_the_evidence_of_use_and_harms_of_novel_benzodiazepines.pdf.
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