Chemistry:N-Methylclonazepam
 | |
| Legal status | |
|---|---|
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| UNII | |
| Chemical and physical data | |
| Formula | C16H12ClN3O3 |
| Molar mass | 329.74 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
N-Methylclonazepam (also known as Ro05-4082, ID-690 and methylclonazepam)[1] is a benzodiazepine derivative developed in the 1970s. It has sedative and hypnotic properties, and has around the same potency as clonazepam itself.[2] It was never introduced into clinical use. It is a structural isomer of meclonazepam (3-methylclonazepam), and similarly has been sold as a designer drug, first being identified in Sweden in 2017.[3]
In July 2025, N-methylclonazepam was identified alongside fentanyl as a component in a batch of drugs linked to a mass overdose in Baltimore, Maryland.[4][5] There were at least 27 hospitalisations, and many patients remained unconscious even after administration of naloxone; a NIST research chemist said this may have been due to the sedative effects of the methylclonazepam.[4]
See also
References
- ↑ "UNII - 89WG8CN9AJ | UNII Search Service". https://precision.fda.gov/uniisearch/srs/unii/89WG8CN9AJ.
- ↑ "[Pharmacological study on 5-(o-chlorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (ID-690), with special reference to the effects on motor systems]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 73 (1): 123–134. January 1977. doi:10.1254/fpj.73.123. PMID 558942.
- ↑ "Novel Benzodiazepines. A review of the evidence of use and harms of Novel Benzodiazepines.". Advisory Council on the Misuse of Drugs. April 2020. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/881969/ACMD_report_-_a_review_of_the_evidence_of_use_and_harms_of_novel_benzodiazepines.pdf.
- ↑ "Baltimore overdoses may be linked to new drug" (in en-US). The Washington Post. 19 July 2025. ISSN 0190-8286. https://www.washingtonpost.com/dc-md-va/2025/07/19/new-drug-found-baltimore-overdose/.
 |  |
