Chemistry:17-Phenylandrostenol

Short description: Chemical compound

17-Phenylandrostenol

Clinical data
Other names	(3α,5α)-17-Phenyl-androst-16-en-3-ol
Identifiers
IUPAC name (3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-phenyl- 2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
CAS Number	694438-95-4 N
PubChem CID	25068278
ChemSpider	21475142 Y
Chemical and physical data
Formula	C25H34O
Molar mass	350.546 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@]12CC[C@H](C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CC=CC=C5)C)O
InChI InChI=1S/C25H34O/c1-24-14-12-19(26)16-18(24)8-9-20-22-11-10-21(17-6-4-3-5-7-17)25(22,2)15-13-23(20)24/h3-7,10,18-20,22-23,26H,8-9,11-16H2,1-2H3/t18-,19+,20-,22-,23-,24-,25+/m0/s1 Y Key:SINAMTXBCYKFDL-WBJZGETLSA-N Y
NY (what is this?)  (verify)

17-Phenylandrostenol (17-PA), or (3α,5α)-17-phenylandrost-16-en-3-ol, is a steroid drug which binds to GABA_A receptors. It acts as an antagonist against the sedative effects of neuroactive steroids, but has little effect when administered by itself, and does not block the effects of benzodiazepines or barbiturates.

See also

• Androstenol

References

{{Navbox | name = GABA receptor modulators | title = GABA receptor modulators | state = collapsed | bodyclass = hlist | groupstyle = text-align:center;

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   | group1 = GABAA
   | list1  = 

• Agonists: (+)-Catechin
• Bamaluzole
• Barbiturates (e.g., phenobarbital)
• BL-1020
• DAVA
• Dihydromuscimol
• GABA
• Gabamide
• GABOB
• Gaboxadol (THIP)
• Homotaurine (tramiprosate, 3-APS)
• Ibotenic acid
• iso-THAZ
• iso-THIP
• Isoguvacine
• Isomuscimol
• Isonipecotic acid
• Kojic amine
• Lignans (e.g., honokiol)
• Methylglyoxal
• Monastrol
• Muscimol
• Nefiracetam
• Neuroactive steroids (e.g., allopregnanolone)
• Org 20599
• PF-6372865
• Phenibut
• Picamilon
• P4S
• Progabide
• Propofol
• Quisqualamine
• SL-75102
• TACA
• TAMP
• Terpenoids (e.g., borneol)
• Thiomuscimol
• Tolgabide
• ZAPA

• Positive modulators (abridged; see here for a full list): α-EMTBL
• Alcohols (e.g., ethanol)
• Anabolic steroids
• Avermectins (e.g., ivermectin)
• Barbiturates (e.g., phenobarbital)
• Benzodiazepines (e.g., diazepam)
• Bromide compounds (e.g., potassium bromide)
• Carbamates (e.g., meprobamate)
• Carbamazepine
• Chloralose
• Chlormezanone
• Clomethiazole
• Dihydroergolines (e.g., ergoloid (dihydroergotoxine))
• Etazepine
• Etifoxine
• Fenamates (e.g., mefenamic acid)
• Flavonoids (e.g., apigenin, hispidulin)
• Fluoxetine
• Flupirtine
• Imidazoles (e.g., etomidate)
• Kava constituents (e.g., kavain)<!--PMID: 9776662-->
• Lanthanum
• Loreclezole
• Monastrol
• Neuroactive steroids (e.g., allopregnanolone, [[Chemistry:Cholecholesterol]], THDOC)
• Niacin
• Nicotinamide (niacinamide)
• Nonbenzodiazepines (e.g., β-carbolines (e.g., [[abecarnil), cyclopyrrolones (e.g., zopiclone), imidazopyridines (e.g., zolpidem), pyrazolopyrimidines (e.g., zaleplon))
• Norfluoxetine
• Petrichloral
• Phenols (e.g., propofol)
• Phenytoin
• Piperidinediones (e.g., glutethimide)
• Propanidid
• Pyrazolopyridines (e.g., etazolate)
• Quinazolinones (e.g., methaqualone)
• Retigabine (ezogabine)
• ROD-188
• Skullcap constituents (e.g., baicalin)
• Stiripentol
• Sulfonylalkanes (e.g., sulfonmethane (sulfonal))
• Topiramate
• Valerian constituents (e.g., valerenic acid)
• Volatiles/gases (e.g., chloral hydrate, chloroform, [[Chemistry:Diethyl diethyl ether, Parparaldehyde]], sevoflurane)

• Antagonists: Bicuculline
• Coriamyrtin
• Dihydrosecurinine
• Gabazine (SR-95531)
• Hydrastine
• Hyenachin (mellitoxin)
• PHP-501
• Pitrazepin
• Securinine
• Sinomenine
• SR-42641
• SR-95103
• Thiocolchicoside
• Tutin

• Negative modulators: 1,3M1B
• 3M2B
• 11-Ketoprogesterone
• 17-Phenylandrostenol
• α5IA (LS-193,268)
• β-CCB
• β-CCE
• β-CCM
• β-CCP
• β-EMGBL
• Anabolic steroids
• Amiloride
• Anisatin
• β-Lactams (e.g., penicillins, cephalosporins, carbapenems)
• Basmisanil
• Bemegride
• Bicyclic phosphates (TBPS, TBPO, IPTBO)
• BIDN
• Bilobalide
• Bupropion
• CHEB
• Chlorophenylsilatrane
• Cicutoxin
• Cloflubicyne
• Cyclothiazide
• DHEA
• DHEA-S
• Dieldrin
• (+)-DMBB
• DMCM
• DMPC
• EBOB
• Etbicyphat
• FG-7142 (ZK-31906)
• Fiproles (e.g., fipronil)
• Flavonoids (e.g., amentoflavone, oroxylin A)
• Flumazenil
• Fluoroquinolones (e.g., ciprofloxacin)
• Flurothyl
• Furosemide
• Golexanolone
• Iomazenil (¹²³I)
• IPTBO
• Isopregnanolone (sepranolone)
• L-655,708
• Laudanosine
• Leptazol
• Lindane
• MaxiPost
• Morphine
• Morphine-3-glucuronide
• MRK-016
• Naloxone
• Naltrexone
• Nicardipine
• Nonsteroidal antiandrogens (e.g., [[apalutamide, [[Chemistry:Bicalutbicalutamide, Enzalutenzalutamide, Chemistry:Flutamide|flut]]amide]], nilutamide)
• Oenanthotoxin
• Pentylenetetrazol (pentetrazol)
• Phenylsilatrane
• Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin)
• Pregnenolone sulfate
• Propybicyphat
• PWZ-029
• Radequinil
• Ro 15-4513
• Ro 19-4603
• RO4882224
• RO4938581
• Sarmazenil
• SCS
• Suritozole
• TB-21007
• TBOB
• TBPS
• TCS-1105
• Terbequinil
• TETS
• Thujone
• U-93631
• Zinc
• ZK-93426

   | group2 = GABAA-ρ
   | list2  = 

• Agonists: BL-1020
• CACA
• CAMP
• Homohypotaurine
• GABA
• GABOB
• Ibotenic acid
• Isoguvacine
• Muscimol
• N⁴-Chloroacetylcytosine arabinoside
• Picamilon
• Progabide
• TACA
• TAMP
• Thiomuscimol
• Tolgabide

• Positive modulators: Allopregnanolone
• Alphaxolone
• ATHDOC
• Lanthanides

• Antagonists: (S)-2-MeGABA
• (S)-4-ACPBPA
• (S)-4-ACPCA
• 2-MeTACA
• 3-APMPA
• 4-ACPAM
• 4-GBA
• cis-3-ACPBPA
• CGP-36742 (SGS-742)
• DAVA
• Gabazine (SR-95531)
• Gaboxadol (THIP)
• I4AA
• Isonipecotic acid
• Loreclezole
• P4MPA
• P4S
• SKF-97541
• SR-95318
• SR-95813
• TPMPA
• trans-3-ACPBPA
• ZAPA

• Negative modulators: 5α-Dihydroprogesterone
• Bilobalide
• Loreclezole
• Picrotoxin (picrotin, picrotoxinin)
• Pregnanolone
• ROD-188
• THDOC
• Zinc

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 | group2 = Metabotropic

| list2 =

GABAB

Agonists: 1,4-Butanediol 4-Fluorophenibut Aceburic acid Arbaclofen Arbaclofen placarbil Baclofen BL-1020 GABA Gabamide GABOB GBL GHB GHBAL GHV GVL Isovaline Lesogaberan Phenibut Picamilon Progabide Sodium oxybate SKF-97,541 SL 75102 Tolgabide Tolibut Positive modulators: ADX-71441 BHF-177 BHFF BSPP CGP-7930 CGP-13501 GS-39783 rac-BHFF KK-92A Antagonists: 2-Hydroxysaclofen CGP-35348 CGP-46381 CGP-52432 CGP-54626 CGP-55845 CGP-64213 DAVA Homotaurine (tramiprosate, 3-APS) Phaclofen Saclofen SCH-50911 SKF-97541 Negative modulators: Compound 14

 | below = 

See also

Receptor/signaling modulators

GABA_A receptor positive modulators

GABA metabolism/transport modulators

}}