Chemistry:17-Phenylandrostenol

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Short description: Chemical compound
17-Phenylandrostenol
17-Phenylandrostenol.svg
Clinical data
Other names(3α,5α)-17-Phenyl-androst-16-en-3-ol
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC25H34O
Molar mass350.546 g·mol−1
3D model (JSmol)
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17-Phenylandrostenol (17-PA), or (3α,5α)-17-phenylandrost-16-en-3-ol, is a steroid drug which binds to GABAA receptors. It acts as an antagonist against the sedative effects of neuroactive steroids, but has little effect when administered by itself, and does not block the effects of benzodiazepines or barbiturates.[1][2]

Chemistry

See also

References

  1. "Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors". Molecular Pharmacology 65 (5): 1191–7. May 2004. doi:10.1124/mol.65.5.1191. PMID 15102947. 
  2. "Antagonism of neurosteroid modulation of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol". European Journal of Pharmacology 572 (2–3): 94–101. October 2007. doi:10.1016/j.ejphar.2007.06.028. PMID 17658511. 


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See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators

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