Chemistry:Cloflubicyne

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Cloflubicyne
Cloflubicyne.svg
Names
IUPAC name
5,6-dichloro-3,3-bis(trifluoromethyl)bicyclo[2.2.1]heptane-2,2-dicarbonitrile
Identifiers
3D model (JSmol)
ChemSpider
Properties
C11H6Cl2F6N2
Molar mass 351.07 g·mol−1
Hazards
Main hazards Extremely toxic
Lethal dose or concentration (LD, LC):
0.1 mg/kg (intraperitoneal, mice)[1]
0.2 mg/kg (oral, rats)[2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Cloflubicyne is a chemical compound which is a chlorinated derivative of BIDN. It's an irreversible GABA receptor antagonist with powerful convulsant effects.[3][4][5][6]

See also

References

  1. ↑ Fetisov, V.I.; Maslov, A.A.; Panarin, V.A.; Trefilov, N.V. (August 1992). "Fluoro-containing 'cage' convulsants: inhibition of gamma-aminobutyric acid induced Cl−currents". Journal of Fluorine Chemistry 58 (2–3): 368. doi:10.1016/S0022-1139(00)80833-7. 
  2. ↑ Middleton, W.J; Bingham, E.M (May 1982). "Fluorine-containing 1,1-dicyanoethylenes: their preparation, diels-alder reactions, and derived norbornenes and norbornanes". Journal of Fluorine Chemistry 20 (3): 397–418. doi:10.1016/S0022-1139(00)82232-0. 
  3. ↑ Golovko, A. I.; Sofronov, G. A.; Klyuntina, T. V. (April 1996). "Norbornan, a new irreversible ligand of the GABAA-receptor chloride channels". Bulletin of Experimental Biology and Medicine 121 (4): 404–406. doi:10.1007/BF02446741. 
  4. ↑ Golovko, A. I.; Sofronov, G. A.; Klyuntina, T. V.; Suftin, S. G.; Garbuz, L. A. (July 1996). "Norbornane-induced changes in the density of chloride-ion channels in the brain of rodents". Bulletin of Experimental Biology and Medicine 122 (1): 660–662. doi:10.1007/BF02446014. 
  5. ↑ Golovko, A. I.; Ivanov, M. B.; Klyuntina, T. V.; Sofronov, G. A.; Sviderskii, O. A.; Shilov, V. V. (January 1997). "Development of increased convulsibility in mice after a single norbornan injection". Bulletin of Experimental Biology and Medicine 123 (1): 52–54. doi:10.1007/BF02764378. 
  6. ↑ Golovko, A. I.; Ivanov, M. B.; Sviderskii, O. A.; Sofronov, G. A.; Shilov, V. V. (June 1998). "Mechanisms of kindling induced by norbornan intoxication". Bulletin of Experimental Biology and Medicine 125 (6): 579–581. doi:10.1007/BF02445245. 

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See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators

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