Chemistry:SKF-97,541

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Short description: Chemical compound
SKF-97,541
SKF-97,541.svg
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
Chemical and physical data
FormulaC4H12NO2P
Molar mass137.119 g·mol−1
3D model (JSmol)
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SKF-97,541 is a compound used in scientific research which acts primarily as a selective GABAB receptor agonist.[1] It has sedative effects in animal studies and is widely used in research into potential treatment of various types of drug addiction.[2][3][4][5][6][7][8][9]

References

  1. ↑ "Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices". British Journal of Pharmacology 101 (4): 949–57. December 1990. doi:10.1111/j.1476-5381.1990.tb14186.x. PMID 1964824. 
  2. ↑ "The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep". Experimental Biology and Medicine 227 (5): 315–20. May 2002. doi:10.1177/153537020222700503. PMID 11976401. 
  3. ↑ "GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice". Psychopharmacology 174 (3): 358–66. July 2004. doi:10.1007/s00213-003-1769-3. PMID 14985930. 
  4. ↑ "Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348". European Journal of Pharmacology 538 (1–3): 85–93. May 2006. doi:10.1016/j.ejphar.2006.03.039. PMID 16647701. 
  5. ↑ "Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348". Psychopharmacology 192 (3): 407–14. June 2007. doi:10.1007/s00213-007-0718-y. PMID 17277933. 
  6. ↑ "Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348)". The Journal of Pharmacology and Experimental Therapeutics 330 (3): 876–83. September 2009. doi:10.1124/jpet.109.151845. PMID 19564487. 
  7. ↑ "Effects of GABAB receptor agonists on cocaine hyperlocomotor and sensitizing effects in rats". Pharmacological Reports 61 (6): 1042–9. 2009. doi:10.1016/s1734-1140(09)70166-5. PMID 20081239. 
  8. ↑ "Pharmacological targeting of the GABA B receptor alters Drosophila's behavioural responses to alcohol". Addiction Biology 25 (2): e12725. 2020. doi:10.1111/adb.12725. PMID 30761704. 
  9. ↑ "The impact of GABAB receptors and their pharmacological stimulation on cocaine reinforcement and drug-seeking behaviors in a rat model of depression". European Journal of Pharmacology 883: 173324. September 2020. doi:10.1016/j.ejphar.2020.173324. PMID 32621910. 

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See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators

}}



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