Chemistry:Gamma-Hydroxyvaleric acid

From HandWiki
gamma-Hydroxyvaleric acid
4-Hydroxyvaleric acid.svg
Clinical data
Other namesγ-Hydroxyvaleric acid
GVB
Legal status
Legal status
  • US: DEA considers GHV a controlled substance analogue.[1]
  • In general: uncontrolled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC5H10O3
Molar mass118.132 g·mol−1

γ-Hydroxyvaleric acid (GHV), also known as 4-methyl-GHB, is a designer drug related to γ-hydroxybutyric acid (GHB). It is sometimes seen on the grey market as a legal alternative to GHB, but with lower potency and higher toxicity,[2] properties which have tended to limit its recreational use.[3]

γ-Valerolactone (GVL) acts as a prodrug to GHV, analogously to how γ-butyrolactone (GBL) is a prodrug to GHB.[4]

See also

References

  1. "GHB and Analogues: Fast Facts". January 1, 2006. https://www.justice.gov/archive/ndic/pubs4/4532/index.htm#Top. 
  2. "Comparison of the behavioral effects of gamma-hydroxybutyric acid (GHB) and its 4-methyl-substituted analog, gamma-hydroxyvaleric acid (GHV)". Drug and Alcohol Dependence 78 (1): 91–99. April 2005. doi:10.1016/j.drugalcdep.2004.10.002. PMID 15769562. 
  3. Handbook of Forensic Drug Analysis. Academic Press. 31 December 2004. pp. 462–. ISBN 978-0-08-047289-8. https://books.google.com/books?id=8JsQgRO3QcwC&pg=PA462. 
  4. "Uptake of gamma-valerolactone--detection of gamma-hydroxyvaleric acid in human urine samples". Journal of Analytical Toxicology 37 (4): 250–254. May 2013. doi:10.1093/jat/bkt013. PMID 23486087. 

{{Navbox | name = GABA receptor modulators | title = GABA receptor modulators | state = collapsed | bodyclass = hlist | groupstyle = text-align:center;

 | group1 = Ionotropic
 |  list1 = {{Navbox|subgroup
 | groupstyle = text-align:center
 | groupwidth = 5em
   | group1 = GABAA
   | list1  = 
   | group2 = GABAA
   | list2  = 
 }}
 | group2 = Metabotropic

| list2 =

 | below = 
See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators

}}