Chemistry:A-349821
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Short description: Chemical compound
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| Formula | C26H34N2O3 |
| Molar mass | 422.558 g·mol−1 |
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A-349,821 is a potent and selective histamine H3 receptor antagonist[1] (or possibly an inverse agonist).[2] It has nootropic effects in animal studies,[3] although there do not appear to be any plans for clinical development at present and it is currently only used in laboratory research.[citation needed]
See also
References
- ↑ "Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists". Bioorganic & Medicinal Chemistry Letters 13 (7): 1325–8. April 2003. doi:10.1016/S0960-894X(03)00118-5. PMID 12657274.
- ↑ "Detection of multiple H3 receptor affinity states utilizing [3HA-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand"]. British Journal of Pharmacology 148 (5): 657–70. July 2006. doi:10.1038/sj.bjp.0706752. PMID 16715122.
- ↑ "Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist". Biochemical Pharmacology 68 (5): 933–45. September 2004. doi:10.1016/j.bcp.2004.05.048. PMID 15294456.
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