Chemistry:Thioperamide
From HandWiki
Short description: Chemical compound
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| Formula | C15H24N4S |
| Molar mass | 292.45 g·mol−1 |
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Thioperamide is a potent HRH4 antagonist and selective HRH3 antagonist capable of crossing the blood–brain barrier.[1] It was used by Jean-Charles Schwartz in his early experiments regarding the H3 receptor.[2] Thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine. The drug enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine.
Its action on H3 receptors is thought to promote wakefulness and improve memory consolidation.
See also
- H3 receptor antagonist
References
- ↑ "Thioperamide". IUPHAR/BPS Guide to Pharmacology. https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=biology&ligandId=1267.
- ↑ "The histamine H3 receptor: from discovery to clinical trials with pitolisant". British Journal of Pharmacology 163 (4): 713–21. June 2011. doi:10.1111/j.1476-5381.2011.01286.x. PMID 21615387.
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