Chemistry:JNJ-5207852
From HandWiki
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| Preferred IUPAC name
1-(3-{4-[(piperidin-1-yl)methyl]phenoxy}propyl)piperidine | |
| Identifiers | |
3D model (JSmol)
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| Abbreviations | JNJ-5207852 |
| ChEMBL | |
| ChemSpider | |
| MeSH | JNJ-5207852 |
PubChem CID
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| Properties | |
| C20H32N2O | |
| Molar mass | 316.480 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
Tracking categories (test):
JNJ-5207852 is a histamine antagonist selective for the H3 subtype. It has stimulant and nootropic effects in animal studies,[1] and has been suggested as a possible treatment for some memory defects associated with epilepsy.[2] JNJ-5207852 itself did not progress to clinical development due to poor pharmacokinetic characteristics, but the related compound JNJ-17216498 was in a Phase II clinical trial for the treatment of narcolepsy in 2007.[3]
References
- ↑ "Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist". Br. J. Pharmacol. 143 (5): 649–61. November 2004. doi:10.1038/sj.bjp.0705964. PMID 15466448.
- ↑ "Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice". Neuropharmacology 50 (4): 404–11. Mar 2006. doi:10.1016/j.neuropharm.2005.09.017. PMID 16310812.
- ↑ "The histamine H3 receptor: an attractive target for the treatment of cognitive disorders". Br. J. Pharmacol. 154 (6): 1166–81. July 2008. doi:10.1038/bjp.2008.147. PMID 18469850.
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