4-Methyldiphenhydramine is an antihistamine and anticholinergic .[ 1] [ 2]
It is structurally analogous to diphenhydramine .
References
↑ "The antihistaminic and anticholinergic activities of optically active diphenhydramine derivatives. The concept of complementarity". Arzneimittel-Forschung 21 (5): 688–91. May 1971. PMID 4398311 . ↑ "Changes in antihistaminic and anticholinergic activities of diphenhydramine derivatives on quaternization and the role of an asymmetric centre.". Chimica Therapeutica 7 (4): 279-282. 1972.
mAChRs
Agonists Antagonists
3-Quinuclidinyl benzilate 4-DAMP Aclidinium bromide (+formoterol )Abediterol AF-DX 250 AF-DX 384 Ambutonium bromide Anisodamine Anisodine Antihistamines (first-generation) (e.g., brompheniramine , buclizine , captodiame , chlorphenamine (chlorpheniramine) , cinnarizine , clemastine , cyproheptadine , dimenhydrinate , [[Chemistry:Dimetdimetindene, Diphenhydramine |diphenhydramine]], doxylamine , meclizine , mepyramine (pyrilamine) , mequitazine , perlapine , phenindamine , pheniramine , Phenyltoloxamine|Phenyltoloxamine ]]]], promethazine , propiomazine , triprolidine )AQ-RA 741 Atropine Atropine methonitrate Atypical antipsychotics (e.g., clozapine, Chemistry :Fluperlapine
Precursors (and prodrugs)
nAChRs
Agonists PAMs
5-HIAA A-84,543 A-366,833 A-582,941 A-867,744 ABT-202 ABT-418 ABT-560 ABT-894 Acetylcholine Altinicline Anabasine Anatoxin-a AR-R17779 Bephenium hydroxynaphthoate Butinoline Butyrylcholine Carbachol Choline Cotinine Cytisine Decamethonium Desformylflustrabromine Dianicline Dimethylphenylpiperazinium Epibatidine Epiboxidine Ethanol (alcohol) Ethoxysebacylcholine EVP-4473 EVP-6124 Galantamine GTS-21 Ispronicline Ivermectin JNJ-39393406 Levamisole Lobeline MEM-63,908 (RG-3487) Morantel Nicotine (tobacco )NS-1738 PHA-543,613 PHA-709,829 PNU-120,596 PNU-282,987 Pozanicline Pyrantel Rivanicline RJR-2429 Sazetidine A SB-206553 Sebacylcholine SIB-1508Y SIB-1553A SSR-180,711 Suberyldicholine Suxamethonium (succinylcholine) Suxethonium (succinyldicholine) TC-1698 TC-1734 TC-1827 TC-2216 TC-5214 TC-5619 TC-6683 Tebanicline Tribendimidine Tropisetron UB-165 Varenicline WAY-317,538 XY-4083 Antagonists NAMs
Precursors (and prodrugs)
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