Chemistry:VUF-5681

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VUF-5681
VUF-5681.svg
Names
Preferred IUPAC name
4-[3-(1H-Imidazol-5-yl)propyl]piperidine
Identifiers
3D model (JSmol)
ChemSpider
UNII
Properties
C11H19N3
Molar mass 193.288 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Tracking categories (test):

VUF-5681 is a potent and selective histamine antagonist which binds selectively to the H3 subtype.[1] However while VUF-5681 blocks the activity of more potent H3 agonists, recent studies suggest that it may have some weak partial agonist activity when administered by itself.[2]

References

  1. "Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway". Neuropharmacology 51 (3): 517–23. September 2006. doi:10.1016/j.neuropharm.2006.04.010. PMID 16769092. 
  2. "Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells". BMC Pharmacology 8: 9. June 2008. doi:10.1186/1471-2210-8-9. PMID 18538007.