Chemistry:Pipoxizine

Pipoxizine
Clinical data
ATC code	None;
Identifiers
	IUPAC name 2-(2-{2-[4-(Diphenylmethylene)-1-piperidinyl]ethoxy}ethoxy)ethanol;
CAS Number	55837-21-3;
PubChem CID	68750;
ChemSpider	61995;
UNII	B9A98D632Z;
Chemical and physical data
Formula	C24H31NO3
Molar mass	381.516 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1ccc(cc1)C(=C2CCN(CC2)CCOCCOCCO)c3ccccc3;
	InChI InChI=1S/C24H31NO3/c26-16-18-28-20-19-27-17-15-25-13-11-23(12-14-25)24(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-10,26H,11-20H2; Key:SCMPXORBOTWFTI-UHFFFAOYSA-N;

Short description: Chemical compound

Pipoxizine (INN) is a first-generation antihistamine as well as serotonin antagonist of the diphenylmethylpiperazine group related to hydroxyzine.^[1]^[2] It was investigated as a bronchodilator but was never marketed.^[1]^[3]^[4]

References

↑ ^1.0 ^1.1 Dictionary of Pharmacological Agents. CRC Press. 21 November 1996. pp. 1619–. ISBN 978-0-412-46630-4. https://books.google.com/books?id=A0THacd46ZsC&pg=PA1619.
↑ World Health Organization (1988). International Nonproprietary Names (INN) for Pharmaceutical Substances. W.H.O.. ISBN 9789240560369. https://books.google.com/books?id=dcF1nQEACAAJ.
↑ "Pipoxizine, a New Bronchodilator". Lung 154 (2): 143.
↑ "[Effect of a histamine aerosol in 20 subjects with histamine hyperreactivity. Application to a study of the protective properties of pipoxizine]" (in fr). Revue de l'Institut d'Hygiene des Mines 33 (4): 191–195. 1978. PMID 45187.

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Original source: https://en.wikipedia.org/wiki/Pipoxizine. Read more

[GanellinTriggle1996-1] 1.0 ^1.1 Dictionary of Pharmacological Agents. CRC Press. 21 November 1996. pp. 1619–. ISBN 978-0-412-46630-4. https://books.google.com/books?id=A0THacd46ZsC&pg=PA1619.

[Organization1988-2] World Health Organization (1988). International Nonproprietary Names (INN) for Pharmaceutical Substances. W.H.O.. ISBN 9789240560369. https://books.google.com/books?id=dcF1nQEACAAJ.

[Brunner1997-3] "Pipoxizine, a New Bronchodilator". Lung 154 (2): 143.

[pmid45187-4] "[Effect of a histamine aerosol in 20 subjects with histamine hyperreactivity. Application to a study of the protective properties of pipoxizine]" (in fr). Revue de l'Institut d'Hygiene des Mines 33 (4): 191–195. 1978. PMID 45187.

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v t e Histamine receptor modulators
H₁	Agonists: 2-Pyridylethylamine Betahistine Histamine HTMT L-Histidine UR-AK49 Antagonists: First-generation: 4-Methyldiphenhydramine Alimemazine Antazoline Azatadine Bamipine Benzatropine (benztropine) Bepotastine Bromazine Brompheniramine Buclizine Captodiame Carbinoxamine Chlorcyclizine Chloropyramine Chlorothen Chlorphenamine Chlorphenoxamine Cinnarizine Clemastine Clobenzepam Clocinizine Cloperastine Cyclizine Cyproheptadine Dacemazine Decloxizine Deptropine Dexbrompheniramine Dexchlorpheniramine Dimenhydrinate Dimetindene Diphenhydramine Diphenylpyraline Doxylamine Embramine Etodroxizine Etybenzatropine (ethylbenztropine) Etymemazine Fenethazine Flunarizine Histapyrrodine Homochlorcyclizine Hydroxyethylpromethazine Hydroxyzine Isopromethazine Isothipendyl Meclozine Medrylamine Mepyramine (pyrilamine) Mequitazine Methafurylene Methapyrilene Methdilazine Moxastine Orphenadrine Oxatomide Oxomemazine Perlapine Phenindamine Pheniramine Phenyltoloxamine Pimethixene Piperoxan Pipoxizine Promethazine Propiomazine Pyrrobutamine Talastine Thenalidine Thenyldiamine Thiazinamium Thonzylamine Tolpropamine Tripelennamine Triprolidine Second/third-generation: Acrivastine Alinastine Astemizole Azelastine Bamirastine Barmastine Bepiastine Bepotastine Bilastine Cabastinen Carebastine Cetirizine Clemastine Clemizole Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine Linetastine Loratadine Mapinastine Mebhydrolin Mizolastine Moxastine Noberastine Octastine Olopatadine Perastine Pibaxizine Piclopastine Quifenadine (phencarol) Rocastine Rupatadine Setastine Sequifenadine (bicarphen) Talastine Temelastine Terfenadine Vapitadine Zepastine Others: Atypical antipsychotics (e.g., aripiprazole, asenapine, Chemistry:Brexpiprazole
H₂	Agonists: Amthamine Betazole Dimaprit Histamine HTMT Impromidine L-Histidine UR-AK49 Antagonists: Bisfentidine Burimamide Cimetidine Dalcotidine Donetidine Ebrotidine Etintidine Famotidine Isolamtidine Lafutidine Lamtidine Lavoltidine (loxtidine) Lupitidine Metiamide Mifentidine Niperotidine Nizatidine Osutidine Oxmetidine Pibutidine Quisultazine (quisultidine) Ramixotidine Ranitidine Roxatidine Sufotidine Tiotidine Tuvatidine Venritidine Xaltidine Zolantidine
H₃	Agonists: α-Methylhistamine Cipralisant Histamine Imetit Immepip Immethridine L-Histidine Methimepip Proxyfan Antagonists: A-349,821 A-423,579 ABT-239 ABT-652 AZD5213 Bavisant Betahistine Burimamide Ciproxifan Clobenpropit Conessine Enerisant GSK-189,254 Impentamine Iodophenpropit Irdabisant JNJ-5207852 NNC 38-1049 PF-03654746 Pitolisant SCH-79687 Thioperamide VUF-5681
H₄	Agonists: 4-Methylhistamine α-Methylhistamine Histamine L-Histidine OUP-16 VUF-8430 Antagonists: JNJ-7777120 Mianserin Seliforant Thioperamide Toreforant VUF-6002
See also: Receptor/signaling modulators • Monoamine metabolism modulators • Monoamine reuptake inhibitors

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Clinical data

ATC code	None
Identifiers
IUPAC name 2-(2-{2-[4-(Diphenylmethylene)-1-piperidinyl]ethoxy}ethoxy)ethanol
CAS Number	55837-21-3
PubChem CID	68750
ChemSpider	61995
UNII	B9A98D632Z
Chemical and physical data
Formula	C₂₄H₃₁NO₃
Molar mass	381.516 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c1ccc(cc1)C(=C2CCN(CC2)CCOCCOCCO)c3ccccc3
InChI InChI=1S/C24H31NO3/c26-16-18-28-20-19-27-17-15-25-13-11-23(12-14-25)24(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-10,26H,11-20H2 Key:SCMPXORBOTWFTI-UHFFFAOYSA-N

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