Chemistry:Methafurylene

Methafurylene
Clinical data
ATC code	none;
Identifiers
	IUPAC name N-(2-Furylmethyl)-N′,N′-dimethyl-N-pyridin-2-ylethane-1,2-diamine;
CAS Number	531-06-6;
PubChem CID	21563;
ChemSpider	20265;
UNII	HU5BZT118T;
Chemical and physical data
Formula	C14H19N3O
Molar mass	245.326 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCN(CC1=CC=CO1)C2=CC=CC=N2;
	InChI InChI=1S/C14H19N3O/c1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14/h3-8,11H,9-10,12H2,1-2H3; Key:LUQHAHRMUPOTQK-UHFFFAOYSA-N;
	(verify)

Short description: Chemical compound

Methafurylene is an antihistamine and anticholinergic.^[1]

References

↑ "Pharmacology of N-(2-furfuryl)-N-(2-pyridyl)-N',N'-dimethylethylenediamine fumarat (methafurylene fumarate). I. Antihistaminic properties of this compound and its 5-chloro and 5-bromo derivatives". The Journal of Pharmacology and Experimental Therapeutics 99 (4:1): 479–87. August 1950. PMID 15437326.

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[pmid15437326-1] "Pharmacology of N-(2-furfuryl)-N-(2-pyridyl)-N',N'-dimethylethylenediamine fumarat (methafurylene fumarate). I. Antihistaminic properties of this compound and its 5-chloro and 5-bromo derivatives". The Journal of Pharmacology and Experimental Therapeutics 99 (4:1): 479–87. August 1950. PMID 15437326.

[1]

v t e Histamine receptor modulators
H₁	Agonists: 2-Pyridylethylamine Betahistine Histamine HTMT L-Histidine UR-AK49 Antagonists: First-generation: 4-Methyldiphenhydramine Alimemazine Antazoline Azatadine Bamipine Benzatropine (benztropine) Bepotastine Bromazine Brompheniramine Buclizine Captodiame Carbinoxamine Chlorcyclizine Chloropyramine Chlorothen Chlorphenamine Chlorphenoxamine Cinnarizine Clemastine Clobenzepam Clocinizine Cloperastine Cyclizine Cyproheptadine Dacemazine Decloxizine Deptropine Dexbrompheniramine Dexchlorpheniramine Dimenhydrinate Dimetindene Diphenhydramine Diphenylpyraline Doxylamine Embramine Etodroxizine Etybenzatropine (ethylbenztropine) Etymemazine Fenethazine Flunarizine Histapyrrodine Homochlorcyclizine Hydroxyethylpromethazine Hydroxyzine Isopromethazine Isothipendyl Meclozine Medrylamine Mepyramine (pyrilamine) Mequitazine Methafurylene Methapyrilene Methdilazine Moxastine Orphenadrine Oxatomide Oxomemazine Perlapine Phenindamine Pheniramine Phenyltoloxamine Pimethixene Piperoxan Pipoxizine Promethazine Propiomazine Pyrrobutamine Talastine Thenalidine Thenyldiamine Thiazinamium Thonzylamine Tolpropamine Tripelennamine Triprolidine Second/third-generation: Acrivastine Alinastine Astemizole Azelastine Bamirastine Barmastine Bepiastine Bepotastine Bilastine Cabastinen Carebastine Cetirizine Clemastine Clemizole Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine Linetastine Loratadine Mapinastine Mebhydrolin Mizolastine Moxastine Noberastine Octastine Olopatadine Perastine Pibaxizine Piclopastine Quifenadine (phencarol) Rocastine Rupatadine Setastine Sequifenadine (bicarphen) Talastine Temelastine Terfenadine Vapitadine Zepastine Others: Atypical antipsychotics (e.g., aripiprazole, asenapine, Chemistry:Brexpiprazole
H₂	Agonists: Amthamine Betazole Dimaprit Histamine HTMT Impromidine L-Histidine UR-AK49 Antagonists: Bisfentidine Burimamide Cimetidine Dalcotidine Donetidine Ebrotidine Etintidine Famotidine Isolamtidine Lafutidine Lamtidine Lavoltidine (loxtidine) Lupitidine Metiamide Mifentidine Niperotidine Nizatidine Osutidine Oxmetidine Pibutidine Quisultazine (quisultidine) Ramixotidine Ranitidine Roxatidine Sufotidine Tiotidine Tuvatidine Venritidine Xaltidine Zolantidine
H₃	Agonists: α-Methylhistamine Cipralisant Histamine Imetit Immepip Immethridine L-Histidine Methimepip Proxyfan Antagonists: A-349,821 A-423,579 ABT-239 ABT-652 AZD5213 Bavisant Betahistine Burimamide Ciproxifan Clobenpropit Conessine Enerisant GSK-189,254 Impentamine Iodophenpropit Irdabisant JNJ-5207852 NNC 38-1049 PF-03654746 Pitolisant SCH-79687 Thioperamide VUF-5681
H₄	Agonists: 4-Methylhistamine α-Methylhistamine Histamine L-Histidine OUP-16 VUF-8430 Antagonists: JNJ-7777120 Mianserin Seliforant Thioperamide Toreforant VUF-6002
See also: Receptor/signaling modulators • Monoamine metabolism modulators • Monoamine reuptake inhibitors

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Clinical data

ATC code	none
Identifiers
IUPAC name N-(2-Furylmethyl)-N′,N′-dimethyl-N-pyridin-2-ylethane-1,2-diamine
CAS Number	531-06-6
PubChem CID	21563
ChemSpider	20265
UNII	HU5BZT118T
Chemical and physical data
Formula	C₁₄H₁₉N₃O
Molar mass	245.326 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(C)CCN(CC1=CC=CO1)C2=CC=CC=N2
InChI InChI=1S/C14H19N3O/c1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14/h3-8,11H,9-10,12H2,1-2H3 Key:LUQHAHRMUPOTQK-UHFFFAOYSA-N
(verify)

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Chemistry:Methafurylene

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