Chemistry:Flestolol
From HandWiki
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| Names | |
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| IUPAC name
3-{[1-(Carbamoylamino)-2-methyl-2-propanyl]amino}-2-hydroxypropyl 2-fluorobenzoate
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| Identifiers | |
3D model (JSmol)
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| KEGG | |
PubChem CID
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| Properties | |
| C15H22FN3O4 | |
| Molar mass | 327.356 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
Flestolol is a short-acting beta adrenergic receptor antagonist.[1]
Synthesis
Flestolol synthesis:[2]
Acylation of glycidol (2) with the acid chloride 1 produces the ester 3. Reaction of that intermediate with amine 4, obtained by reaction of 1,1-dimethylethylenediamine with urea, gives flestolol (5).
References
- ↑ Quon, CY; Stampfli, HF (1993). "Biochemical characterization of flestolol esterase". Research communications in chemical pathology and pharmacology 81 (3): 309–22. PMID 8235065.
- ↑ Kam, Sheung Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; O'Donnell, John P.; Stampfli, Herman F.; Sum, Check Y. et al. (1984). "[(Arylcarbonyl)oxy]propanolamines. 1. Novel .beta.-blockers with ultrashort duration of action". Journal of Medicinal Chemistry 27 (8): 1007. doi:10.1021/jm00374a013. PMID 6146718.
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