Chemistry:Melevodopa

Melevodopa, also known as levodopa methyl ester (LDME) and sold under the brand name Levomet, is a dopaminergic agent. It is the methyl ester of levodopa.^[1] It is used in oral tablet form as an effervescent prodrug with 250 times the water solubility of tablet levodopa.^[2]^[3] In combination with carbidopa, as melevodopa/carbidopa (brand name Sirio), it is approved for use in the treatment of Parkinson's disease.^[4]^[5]

References

↑ Dictionary of Alkaloids with CD-ROM. CRC Press. 2010. p. 103. ISBN 978-1-4200-7770-4. https://books.google.com/books?id=mynNBQAAQBAJ&pg=PA103. Retrieved 28 September 2024.
↑ "Available and emerging treatments for Parkinson's disease: a review". Drug Design, Development and Therapy 5: 241–254. 2011. doi:10.2147/DDDT.S11836. PMID 21607020.
↑ "Factors associated with motor fluctuations and dyskinesia in Parkinson Disease: potential role of a new melevodopa plus carbidopa formulation (Sirio)". Clin Neuropharmacol 33 (4): 198–203. July 2010. doi:10.1097/WNF.0b013e3181de8924. PMID 20414107.
↑ "Melevodopa/carbidopa". AdisInsight. Springer Nature Switzerland AG. 23 September 2021. https://adisinsight.springer.com/drugs/800010247.
↑ "Melevodopa: Uses, Interactions, Mechanism of Action". 1 April 2015. https://go.drugbank.com/drugs/DB13313.

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Original source: https://en.wikipedia.org/wiki/Melevodopa. Read more

[BuckinghamBaggaleyRoberts2010-1] Dictionary of Alkaloids with CD-ROM. CRC Press. 2010. p. 103. ISBN 978-1-4200-7770-4. https://books.google.com/books?id=mynNBQAAQBAJ&pg=PA103. Retrieved 28 September 2024.

[HickeyStacy2011-2] "Available and emerging treatments for Parkinson's disease: a review". Drug Design, Development and Therapy 5: 241–254. 2011. doi:10.2147/DDDT.S11836. PMID 21607020.

[StocchiMarconi2010-3] "Factors associated with motor fluctuations and dyskinesia in Parkinson Disease: potential role of a new melevodopa plus carbidopa formulation (Sirio)". Clin Neuropharmacol 33 (4): 198–203. July 2010. doi:10.1097/WNF.0b013e3181de8924. PMID 20414107.

[AdisInsight-4] "Melevodopa/carbidopa". AdisInsight. Springer Nature Switzerland AG. 23 September 2021. https://adisinsight.springer.com/drugs/800010247.

[DrugBank-5] "Melevodopa: Uses, Interactions, Mechanism of Action". 1 April 2015. https://go.drugbank.com/drugs/DB13313.

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