Chemistry:Methoxyphenamine
From HandWiki
Short description: Pair of enantiomers
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AHFS/Drugs.com | International Drug Names |
Routes of administration | Oral |
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Formula | C11H17NO |
Molar mass | 179.263 g·mol−1 |
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Methoxyphenamine (trade names ASMI, Euspirol, Orthoxine, Ortodrinex, Proasma), also known as 2-methoxy-N-methylamphetamine (OMMA), is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.[1]
It acts as an anti-inflammatory in rats.[2]
Chemistry
Methoxyphenamine was first synthesized at the Upjohn company by Woodruff and co-workers.[3] A later synthesis by Heinzelman, from the same company, corrects the melting point given for methoxyphenamine hydrochloride in the earlier paper, and describes an improved synthetic procedure, as well as resolution of the racemic methoxyphenamine.[4]
See also
- 2-Methoxyamphetamine (OMA)
- 3-Methoxy-N-methylamphetamine (MMMA)
- 4-Methoxy-N-methylamphetamine (PMMA)
References
- ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA670.
- ↑ "Anti-inflammatory effect of methoxyphenamine compound in rat model of chronic obstructive pulmonary disease". Acta Pharmacologica Sinica 24 (12): 1324–7. December 2003. PMID 14653967. http://www.chinaphar.com/article/view/8994/9677.
- ↑ "Physiologically active amines. III. Secondary and tertiary β-phenylpropylamines and β-phenylisopropylamines.". Journal of the American Chemical Society 62 (4): 922–4. April 1940. doi:10.1021/ja01861a060.
- ↑ "Physiologically active secondary amines. β-(o-Methoxyphenyl)-isopropyl-N-methylamine and related compounds.". Journal of the American Chemical Society 75 (4): 921–5. February 1953. doi:10.1021/ja01100a043.
Original source: https://en.wikipedia.org/wiki/Methoxyphenamine.
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