Chemistry:SR 59230A
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| Preferred IUPAC name
(2S)-1-(2-Ethylphenoxy)-3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]amino}propan-2-ol | |
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3D model (JSmol)
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| Properties | |
| C21H27NO2 | |
| Molar mass | 325.452 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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SR 59230A is a selective antagonist of the beta-3 adrenergic receptor,[1][2][3] but was subsequently shown to also act at α1 adrenoceptors at high doses.[4] It has been shown to block the hyperthermia produced by MDMA in animal studies.[5]
References
- ↑ "Functional studies of the first selective β3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes". Mol. Pharmacol. 49 (1): 7–14. 1996. PMID 8569714.
- ↑ "The adrenergic receptor subtypes present in frog (Rana esculenta) skin". Comp. Biochem. Physiol. C 148 (2): 160–4. August 2008. doi:10.1016/j.cbpc.2008.05.001. PMID 18544474.
- ↑ "Role of beta1-, beta2-, and beta3-adrenoceptors in contractile hypersensitivity in a model of small bowel transplantation". Surgery 143 (1): 94–102. January 2008. doi:10.1016/j.surg.2007.06.034. PMID 18154937.
- ↑ "Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery". J. Pharmacol. Exp. Ther. 309 (1): 137–45. April 2004. doi:10.1124/jpet.103.061192. PMID 14718590.
- ↑ "Role of alpha(1)- and beta(3)-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse". British Journal of Pharmacology 158 (1): 259–66. April 2009. doi:10.1111/j.1476-5381.2009.00186.x. PMID 19422394.
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