Chemistry:Tulobuterol
From HandWiki
Tulobuterol (INN) is a long-acting beta2-adrenergic receptor agonist, marketed in Japan as a transdermal patch under the name Hokunalin tape (ホクナリンテープ).[1]
Currently, it is only legal in 7 countries: Japan, Germany, China, South Korea, Bangladesh, Pakistan, and Venezuela. It is available in India also.
Synthesis
- 500px
The oxidation of 2'-chloroacetophenone (1) with selenium dioxide gives o-chlorophenylglyoxal (2). Condensation with tert-butylamine gives the imine (3). Reduction with sodium borohydride completes the synthesis of tulobuterol.[2]
References
- ↑ "Clinical evaluation of a transdermal therapeutic system of the beta2-agonist tulobuterol in patients with mild or moderate persistent bronchial asthma". Arzneimittel-Forschung 54 (5): 280–5. 2011. doi:10.1055/s-0031-1296971. PMID 15212190.
- ↑ "Development of a New Process for Tulobuterol Hydrochloride". Pharmaceutical Fronts 05: e31–e37. 2023. doi:10.1055/s-0043-1764464.
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