Chemistry:Corbadrine

From HandWiki

Corbadrine, sold under the brand name Neo-Cobefrine and also known as levonordefrin and α-methylnorepinephrine, is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States.[1][2][3] It is usually used in a pre-mixed solution with local anesthetics, such as mepivacaine.[4]

The drug acts as a non-selective agonist of the α1-, α2-, and β-adrenergic receptors.[5][6][7] It is said to have preferential activity at the α2-adrenergic receptor.[5][7]

Corbadrine is also a metabolite of the antihypertensive drug methyldopa and plays a role in its pharmacology and effects.[8]

Pharmacology

Pharmacokinetics

Corbadrine is metabolized primarily by catechol O-methyltransferase (COMT).[7]

Chemistry

Corbadrine, also known as 3,4,β-trihydroxy-α-methylphenethylamine or as 3,4,β-trihydroxyamphetamine, as well as α-methylnorepinephrine or (–)-3,4-dihydroxynorephedrine, is a substituted phenethylamine and amphetamine derivative.[1][3]

Analogues of corbadrine include α-methyldopamine, dioxifedrine (3,4-dihydroxyephedrine; α-methylepinephrine), dioxethedrin (3,4-dihydroxy-N-ethylnorephedrine; α-methyl-N-ethylnorepinephrine), and hydroxyamphetamine (4-hydroxyamphetamine; α-methyltyramine).

Society and culture

Names

Corbadrine is the generic name of the drug and its INN.[1][3][2] It is also known as levonordefrin, which is its USAN.[1][3][2] Synonyms of corbadrine include α-methylnorepinephrine and (–)-3,4-dihydroxynorephedrine.[9] The drug has been sold under the brand name Neo-Cobefrine.[3]

References

  1. ↑ 1.0 1.1 1.2 1.3 Elks, J. (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 55. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA55. Retrieved 30 August 2024. 
  2. ↑ 2.0 2.1 2.2 Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999. pp. 164–. ISBN 978-0-7514-0499-9. https://books.google.com/books?id=mqaOMOtk61IC&pg=PA164. 
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 275–. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA275. 
  4. ↑ "DailyMed — Search results for levonordefrin". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=53eda85c-65cd-4d6c-b4b7-eb3ae2942ed0. 
  5. ↑ 5.0 5.1 Logothetis, D.D. (2016). Local Anesthesia for the Dental Hygienist. Elsevier Health Sciences. p. 46. ISBN 978-0-323-43050-0. https://books.google.com/books?id=hUHdCwAAQBAJ&pg=PA46. Retrieved 30 August 2024. 
  6. ↑ Abraham, Donald J. (15 January 2003). Burger's Medicinal Chemistry and Drug Discovery. Wiley. doi:10.1002/0471266949.bmc093. ISBN 978-0-471-26694-5. 
  7. ↑ 7.0 7.1 7.2 "Vasoconstrictors: indications and precautions". Dent Clin North Am 46 (4): 733–746, ix. October 2002. doi:10.1016/s0011-8532(02)00021-6. PMID 12436828. 
  8. ↑ "Studies on the Metabolism and Mechanism of Action of Methyldopa". Circulation 28 (4): 492–502. October 1963. doi:10.1161/01.CIR.28.4.492. PMID 14068757. 
  9. ↑ "Levonordefrin". https://pubchem.ncbi.nlm.nih.gov/compound/164739. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:Corbadrine&oldid=4038310"