Chemistry:Denopamine
From HandWiki
Short description: Chemical compound
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral (tablets) |
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| Formula | C18H23NO4 |
| Molar mass | 317.385 g·mol−1 |
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Denopamine (INN) is a cardiotonic drug which acts as a β1 adrenergic receptor agonist.[1] It is used in the treatment of angina[2] and may also have potential uses in the treatment of congestive heart failure[3] and for clearing pulmonary oedema.[4] It is marketed in Japan under the brand name Kalgut (カルグート) and available as tablets of 5 and 10 mg, and 5% fine granules.[5]
References
- ↑ "Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator". Current Medical Research and Opinion 18 (7): 407–13. 2002. doi:10.1185/030079902125001119. PMID 12487507.
- ↑ "Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment". International Journal of Cardiology 108 (2): 281–3. April 2006. doi:10.1016/j.ijcard.2005.03.012. PMID 15913812.
- ↑ "Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart". Journal of the American College of Cardiology 32 (3): 808–15. September 1998. doi:10.1016/S0735-1097(98)00314-3. PMID 9741531.
- ↑ "Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs". Japanese Journal of Pharmacology 85 (2): 161–6. February 2001. doi:10.1254/jjp.85.161. PMID 11286398.
- ↑ "Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information" (in Japanese). Mitsubishi Tanabe Pharma Corporation. http://medical.mt-pharma.co.jp/di/file/dc/kal.pdf.
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