Chemistry:Reproterol
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Short description: Chemical compound
-Reproterol_Structural_Formula_V1.svg) | |
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Inhalation (MDI), IV |
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| Chemical and physical data | |
| Formula | C18H23N5O5 |
| Molar mass | 389.412 g·mol−1 |
| 3D model (JSmol) | |
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Reproterol is a short-acting[1] β2 adrenoreceptor agonist used in the treatment of asthma.[2]
It was patented in 1965 and came into medical use in 1977.[3]
Stereochemistry
Reproterol contains a stereocenter and is chiral. There are thus two enantiomers, the (R)-form and the (S)-form. The commercial preparations contain the drug as a racemate, an equal mixture of the two enantiomers.[4]
| Enantiomers of reproterol | |
|---|---|
-Reproterol_Structural_Formula_V1.svg) (R)-Reproterol CAS number: 210710-33-1 |
-Reproterol_Structural_Formula_V1.svg) (S)-Reproterol CAS number: 210710-34-2 |
References
- ↑ "Cromoglycate, reproterol, or both--what's best for exercise-induced asthma?". Sleep & Breathing = Schlaf & Atmung 16 (4): 1229–35. December 2012. doi:10.1007/s11325-011-0638-2. PMID 22198635.
- ↑ "Reproterol: beta-2-agonist, theophylline, or both?". Respiration; International Review of Thoracic Diseases 66 (3): 210–1. 1999. doi:10.1159/000029379. PMID 10364735.
- ↑ (in en) Analogue-based Drug Discovery. John Wiley & Sons. 2006. p. 54X. ISBN 9783527607495. https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA54X.
- ↑ Rote Liste 2017 – Arzneimittelverzeichnis für Deutschland (einschließlich EU-Zulassungen und bestimmter Medizinprodukte). 57. Frankfurt/Main: Rote Liste Service GmbH. 2017. p. 196. ISBN 978-3-946057-10-9.
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