Chemistry:6-Fluoronorepinephrine
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Short description: Chemical compound
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Formula | C8H10FNO3 |
Molar mass | 187.170 g·mol−1 |
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6-Fluoronorepinephrine (6-FNE) is a selective α1- and α2-adrenergic receptor full agonist related to norepinephrine.[1][2] It is the only selective full agonist for the α-adrenergic receptors known to date and has been used to study their function in scientific research.[2] Infusion of 6-FNE into the locus coeruleus of rodents produces marked hyperactivity and behavioral disinhibition by suppressing activity in the area via stimulation of α1-adrenergic receptors.[2][3]
References
- ↑ "Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines". Journal of Medicinal Chemistry 22 (12): 1493–7. 1979. doi:10.1021/jm00198a012. PMID 231654.
- ↑ 2.0 2.1 2.2 "Marked behavioral activation from inhibitory stimulation of locus coeruleus α1-adrenoceptors by a full agonist". Brain Research 1291: 21–31. 2009. doi:10.1016/j.brainres.2009.07.049. PMID 19632210.
- ↑ "Role of epinephrine stimulation of CNS α1-adrenoceptors in motor activity in mice". Synapse 49 (1): 67–76. 2003. doi:10.1002/syn.10212. PMID 12710017.
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