Chemistry:Pronethalol

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Short description: Chemical compound
Pronethalol
Pronethalol.svg
Clinical data
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • Withdrawn
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC15H19NO
Molar mass229.323 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture

Pronethalol (also known as nethalide or compound 38,174; trade name Alderlin) was an early non-selective beta blocker clinical candidate. It was the first beta blocker to be developed by James Black and associates at Imperial Chemical Industries, and the first to enter clinical use, in November 1963.[1]

However, it was never used widely due to carcinogenicity in mice, which was thought to result from formation of a carcinogenic naphthalene epoxide metabolite,[2] and was superseded by propranolol from 1965 onward.[1]

See also

References