Chemistry:Atiprosin
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Short description: Chemical compound
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| Other names | AY-28,228 |
| Routes of administration | Oral |
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| Formula | C20H29N3 |
| Molar mass | 311.473 g·mol−1 |
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Atiprosin (developmental code name AY-28,228) is an antihypertensive agent which acts as a selective α1-adrenergic receptor antagonist.[1][2][3][4] It also possesses some antihistamine activity, though it is some 15-fold weaker in this regard than as an alpha blocker.[3] It was never marketed.[1]
See also
References
- ↑ 1.0 1.1 David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. https://books.google.com/books?id=DeX7jgInYFMC&q=atiprosin&pg=PA189.
- ↑ "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medicinal Chemistry 30 (2): 388–94. February 1987. doi:10.1021/jm00385a022. PMID 3806618.
- ↑ 3.0 3.1 "In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound". Journal of Cardiovascular Pharmacology 10 (3): 249–58. September 1987. doi:10.1097/00005344-198709000-00001. PMID 2444771.
- ↑ "Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys". Journal of Cardiovascular Pharmacology 10 (3): 341–9. September 1987. doi:10.1097/00005344-198709000-00014. PMID 2444784.
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