Chemistry:Imiloxan
From HandWiki
Short description: Chemical compound
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| Formula | C14H16N2O2 |
| Molar mass | 244.294 g·mol−1 |
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Imiloxan is a drug which is used in scientific research. It acts as a selective antagonist for the α2B adrenergic receptor,[1] and has been useful for distinguishing the actions of the different α2 adrenergic subtypes.[2][3]
Synthesis
Imiloxan Synthesis:[4]
The imidazole portion of imiloxan is prepared by the reaction of an imidate with the diethyl acetal of aminoacetaldehyde. N-Alkylation of the imidazole with ethyl iodide gives imiloxan.
References
- ↑ "Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist". British Journal of Pharmacology 99 (3): 560–4. March 1990. doi:10.1111/j.1476-5381.1990.tb12968.x. PMID 1970500.
- ↑ "Pharmacological evidence that alpha2A- and alpha2C-adrenoceptors mediate the inhibition of cardioaccelerator sympathetic outflow in pithed rats". European Journal of Pharmacology 554 (2–3): 205–11. January 2007. doi:10.1016/j.ejphar.2006.09.068. PMID 17109851.
- ↑ "Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine". European Journal of Pharmacology 608 (1–3): 23–7. April 2009. doi:10.1016/j.ejphar.2009.02.019. PMID 19236861.
- ↑ "Structure-activity relationships for 2-substituted imidazoles as alpha 2-adrenoceptor antagonists". Journal of Medicinal Chemistry 25 (6): 666–70. June 1982. doi:10.1021/jm00348a012. PMID 6124635.
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