Chemistry:Oxypertine
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Short description: Antipsychotic medication
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | By mouth |
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| Formula | C23H29N3O2 |
| Molar mass | 379.504 g·mol−1 |
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Oxypertine (Equipertine, Forit, Integrin, Lanturil, Lotawin, Opertil) is an antipsychotic used in the treatment of schizophrenia.[1] It was also evaluated for the treatment of anxiety at a dosage of 20 mg per day.[2] Chemically, it is an indole and phenylpiperazine derivative.[3] Like reserpine and tetrabenazine, oxypertine depletes catecholamines, though not serotonin, possibly underlying its neuroleptic efficacy.[4] Its structure is similar to solypertine and milipertine.
See also
- Monoamine-depleting agent
References
- ↑ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. https://books.google.com/books?id=5S_uhYzKWisC&q=oxypertine%20forit&pg=PA5038.
- ↑ "[Clinical evaluation of oxypertine in anxiety conditions]" (in es). Neurologia, Neurocirugia, Psiquiatria 17 (3): 171–180. 1976. PMID 12484.
- ↑ "[Oxypertine, peperazine derivative of tryptophan with neuroleptic and dynamogenic properties]" (in fr). Acta Neurologica et Psychiatrica Belgica 68 (2): 116–127. February 1968. PMID 4972600.
- ↑ "Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin". Zeitschrift Fur Zellforschung und Mikroskopische Anatomie 101 (3): 448–462. 1969. doi:10.1007/BF00335580. PMID 5362847.
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