Chemistry:L-765,314
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Short description: Chemical compound
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| Formula | C27H34N6O5 |
| Molar mass | 522.606 g·mol−1 |
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L-765,314 is a drug which acts as a potent and selective antagonist of the α1-adrenergic receptor subtype α1B.[1] It has mainly been used to investigate the role of α1B-adrenergic receptors in the regulation of blood pressure.[2][3] The α1B receptor is also thought to have an important role in the brain; however, L-765,314 does not cross the [[blood–brain barrier.[4]
References
- ↑ 4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- <nowiki>journal=Journal of Medicinal Chemistry. 41. April 1998. pp. 1205–8. doi:10.1021/jm980053f. PMID 9548811.
- ↑ "Effects of L-765,314, a selective and potent alpha 1B-adrenoceptor antagonist, on periarterial nerve electrical stimulation-induced double-peaked constrictor responses in isolated dog splenic arteries". Japanese Journal of Pharmacology 89 (4): 429–32. August 2002. doi:10.1254/jjp.89.429. PMID 12233824.
- ↑ "Phenylephrine contracts porcine pulmonary veins via alpha(1B)-, alpha(1D)-, and alpha(2)-adrenoceptors". European Journal of Pharmacology 613 (1–3): 86–92. June 2009. doi:10.1016/j.ejphar.2009.04.011. PMID 19376108.
- ↑ "Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus". The Journal of Pharmacology and Experimental Therapeutics 321 (3): 1062–8. June 2007. doi:10.1124/jpet.106.119297. PMID 17337632.
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