Chemistry:2-Hydroxysaclofen

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2-Hydroxysaclofen is a GABAB receptor antagonist and an analogue of saclofen.

Pharmacodynamics

2-Hydroxysaclofen binds to the GABAB receptor, but this is selective for the (S)-enantiomer, while the (R)-enantiomer does not bind to the GABAB protein.[1]

2-Hydroxysaclofen has been reported to be more potent than saclofen.[2]

See also

References

  1. ↑ "2 Hydroxysaclofen - an overview | ScienceDirect Topics". https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/2-hydroxysaclofen. 
  2. ↑ "2-Hydroxysaclofen". https://www.tocris.com/products/2-hydroxysaclofen_0245. 

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See also
Receptor/signaling modulators
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GABA metabolism/transport modulators

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