Chemistry:ADRIANA
From HandWiki
ADRIANA is a selective α2B-adrenergic receptor antagonist.[1] It is described as highly selective over the α2A- and α2C-adrenergic receptors.[1] The drug stimulates norepinephrine release in the spinal dorsal horn and has potent analgesic effects in rodents and non-human primates.[1] It is orally active.[1] ADRIANA was first described in the scientific literature by Masayasu Toyomoto and colleagues in 2025.[1] It is said to be the first selective α2B-adrenergic receptor antagonist to have been developed.[1]
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "Discovery and development of an oral analgesic targeting the α2B adrenoceptor". Proceedings of the National Academy of Sciences of the United States of America 122 (32). August 2025. doi:10.1073/pnas.2500006122. PMID 40773228. Bibcode: 2025PNAS..12200006T.
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