Chemistry:ADX-71441

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ADX-71441 is a GABAB receptor positive allosteric modulator currently being investigated as a potential treatment for anxiety, epilepsy, pain and other conditions.

Therapeutic potential

Addiction

ADX-71441 has been shown to reduce alcohol consumption.[1] This result was observed in both alcohol dependent and non-dependent animals.[2][3]

There were also trials about nicotine addiction, which showed positive results: ADX-71441 was able to decrease some withdrawal symptoms of nicotine withdrawal.[4]

Anxiety

This compound has also been shown to reduce anxiety in people with PTSD.[5]

Pain

Experiments have shown that this compound was able to decrease hypersensitivity to pain in mice, Guinea pigs and rats.[5]

Tolerance

ADX-71441 has been shown to have less tolerance and side effects than direct GABAB agonists, such as baclofen.[2]

See also

References

  1. ↑ "Addex Reports ADX71441 Reduces Alcohol Intake in a Preclinical Model of Chronic Alcohol Dependence" (in en). https://www.addextherapeutics.com/en/investors/press-releases/addex-reports-adx71441-reduces-alcohol-intake-preclinical-model-chronic-alcohol-dependence/. 
  2. ↑ 2.0 2.1 "The GABAB Positive Allosteric Modulator ADX71441 Attenuates Alcohol Self-Administration and Relapse to Alcohol Seeking in Rats". Neuropsychopharmacology 42 (9): 1789–1799. August 2017. doi:10.1038/npp.2017.53. PMID 28294133. 
  3. ↑ "Positive allosteric modulators of the GABAB receptor: a new class of ligands with therapeutic potential for alcohol use disorder". Alcohol and Alcoholism (Oxford, Oxfordshire) 59 (3). March 2024. doi:10.1093/alcalc/agae018. PMID 38566580. 
  4. ↑ "Addex ADX71441 Positive Results in Preclinical Model of Nicotine Addiction" (in en). https://www.addextherapeutics.com/en/investors/press-releases/addex-adx71441-positive-results-preclinical-model-nicotine-addiction/. 
  5. ↑ 5.0 5.1 "The drug candidate, ADX71441, is a novel, potent and selective positive allosteric modulator of the GABAB receptor with a potential for treatment of anxiety, pain and spasticity". Neuropharmacology 114: 34–47. March 2017. doi:10.1016/j.neuropharm.2016.11.016. PMID 27889489. 

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See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators

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