Chemistry:INDV-1000

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INDV-1000 is a GABAB receptor positive allosteric modulator (PAM) which is under development for the treatment of substance-related disorders.[1][2][3] Its route of administration is unspecified.[1] The drug is under development by Indivior in partnership with Addex Therapeutics.[1][2][3] As of April 2024, it is in the preclinical research stage of development.[1][2][3] The chemical structure of INDV-1000 does not yet appear to have been disclosed.[1] It is one of a limited number of known GABAB receptor PAMs as of 2024.[4][5]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 "INDV 1000". 29 February 2024. https://adisinsight.springer.com/drugs/800056548. 
  2. ↑ 2.0 2.1 2.2 "Delving into the Latest Updates on INDV-1000 with Synapse". 27 May 2025. https://synapse.patsnap.com/drug/fdf7ef309ff64b67adc82c69cd4316ed. 
  3. ↑ 3.0 3.1 3.2 "Addex stock tanks after lead drug flops in Phase II epilepsy trial". 30 April 2024. https://www.clinicaltrialsarena.com/news/addex-stock-tanks-after-lead-drug-flops-in-phase-ii-epilepsy-trial/. "Addex has also partnered with Indivior and is developing the gamma-aminobutyric acid subtype B (GABA-B) PAM asset, INDV-1000. The therapy is in preclinical development, with plans to select drug candidates for an investigational new drug (IND), enabling studies in June for the substance use disorder and chronic cough programs." 
  4. ↑ "Positive allosteric modulators of the GABAB receptor: a new class of ligands with therapeutic potential for alcohol use disorder". Alcohol and Alcoholism 59 (3). March 2024. doi:10.1093/alcalc/agae018. PMID 38566580. 
  5. ↑ "Recent Advances on the Chemistry of GABAB Receptor Allosteric Modulators". GABAB Receptor. The Receptors. Cham: Springer International Publishing. 2024. pp. 169–200. doi:10.1007/978-3-031-67148-7_8. ISBN 978-3-031-67147-0. https://link.springer.com/10.1007/978-3-031-67148-7_8. Retrieved 28 January 2026. 

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See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators

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