Chemistry:Metazosin
From HandWiki
Metazosin is an antihypertensive α1-adrenergic receptor antagonist.[1][2]
Synthesis
- upright=2
The amide (3) is formed when piperazine is reacted with 2-methoxypropionylchloride (2). Metazosin is the product when this intermediate is reacted with the substituted quinazoline (4).[3][4]
References
- ↑ Trcka, V; König, J; Mácová, S; Smíd, M; Helfert, I; Votavová, M; Remesová, J; Nezádalová, E (1990). "Pharmacology of a new antihypertensive agent, metazosin (Kenosin)". Ceskoslovenska Farmacie 39 (6): 266–74. PMID 1981860.
- ↑ Lapka, R; Rejholec, V; Sechser, T; Peterková, M; Smíd, M (1989). "Interspecies pharmacokinetic scaling of metazosin, a novel alpha-adrenergic antagonist". Biopharmaceutics & Drug Disposition 10 (6): 581–9. doi:10.1002/bdd.2510100607. PMID 2575403.
- ↑ Jan Koenig, Miroslav Rajsner, Vaclav Trcka, Sverluse Macova, "Substituted acylpiperazinoquinazolines and pharmaceutical compositions containing same", US patent 4775673, issued 1988-10-04, assigned to Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
- ↑ "Metazosin". https://www.chemdrug.com/article/8/3284/16419996.html.
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