Astronomy:Extraterrestrial sample curation
The curation of extraterrestrial samples (astromaterials) obtained by sample-return missions take place at facilities specially designed to preserve both the sample integrity and protect the Earth. Astromaterials are classified as either non-restricted or restricted, depending on the nature of the Solar System body. Non-restricted samples include the Moon, asteroids, comets, solar particles and space dust. Restricted bodies include planets or moons suspected to have either past or present habitable environments to microscopic life, and therefore must be treated as extremely biohazardous.
Spacecraft instruments are subject to mass and power constraints, in addition of the limitations imposed by the extreme environment of outer space on the sensitive science instruments, so bringing extraterrestrial material to Earth is desired for extensive scientific analyses. For the purpose of planetary protection, astromaterial samples brought to Earth by sample-return missions must be received and curated in a specially-designed and equipped biocontainment facility that must also double as a cleanroom to preserve the science value of the samples.
Samples brought from non-restricted bodies such as the Moon, asteroids, comets, solar particles and space dust, are processed at specialized facilities rated Biosafety level-3 (BSL-3). Samples brought to Earth from a planet or moon suspected to have either past or present habitable environments to microscopic life would make it a Category V body, and must be curated at facilities rated Biosafety level-4 (BSL-4), as agreed in the Article IX of the Outer Space Treaty. However, the existing BSL-4 facilities in the world do not have the complex requirements to ensure the preservation and protection of Earth and the sample simultaneously. While existing BSL-4 facilities deal primarily with fairly well-known organisms, a BSL-4 facility focused on extraterrestrial samples must pre-plan the systems carefully while being mindful that there will be unforeseen issues during sample evaluation and curation that will require independent thinking and solutions. A challenge is that, while it is relatively easy to simply contain the samples once returned to Earth, researchers will want to take a portion and perform analyses. During all these handling procedures, the samples would need to be protected from Earthly contamination and from contact with the atmosphere.
As of 2019, only the Japanese space agency JAXA and the United States space agency NASA operate BSL-3 laboratories in the world exclusively dedicated to the curation of samples from non-restricted bodies. The key feature of JAXA's curation facility, the Extraterrestrial Sample Curation Center, is the ability to observe, take out a portion and preserve a precious return-sample without being exposed to the atmosphere and other contaminants.
Return-samples obtained from a Category V body, must be curated at facilities rated Biosafety level-4 (BSL-4). Because the existing BSL-4 facilities in the world do not have the complex requirements to ensure the preservation and protection of Earth and the sample simultaneously, there are currently at least two proposals to build a BSL-4 facility dedicated to curation of restricted (potentially biohazard) extraterrestrial materials.
The first is the European Sample Curation Facility (ESCF), proposed to be built in Vienna, would curate non-restricted samples as well as BSL-4 biocontainment of restricted material obtained from Category V bodies such as Mars, Europa, Enceladus, etc.
The other proposal is by NASA and is tentatively known as the Mars Sample-Return Receiving Facility (MSRRF). At least three different designs were submitted in 2009. If funded, this American facility would be expected to take 7 to 10 years from design to completion, and an additional two years is recommended for the staff to become proficient and accustomed to the facilities. NASA is also assessing a 2017 proposal to build a mobile and modular BSL-4 facility to secure a sample return capsule at the landing site to conduct preliminary biohazard analyses. After completion of biohazard testing, decisions could be made to sterilize the sample or transport all or portions to a permanent quarantine storage facility anywhere in the world.
The systems of such facilities must be able to contain unknown biohazards, as the sizes of any putative alien microorganisms or infectious agents are unknown. Ideally it should filter particles of 0.01 μm or larger, and release of a particle 0.05 μm or larger is unacceptable under any circumstance. The reason for this extremely small size limit of 0.01 μm is for consideration of gene transfer agents (GTAs) which are virus-like particles that are produced by some microorganisms that package random segments of DNA capable of horizontal gene transfer. These randomly incorporate segments of the host genome and can transfer them to other evolutionarily distant hosts, and do that without killing the new host. In this way many archaea and bacteria can swap DNA with each other. This raises the possibility that Martian life, if it has a common origin with Earth life in the distant past, could swap DNA with Earth microorganisms in the same way. Another reason for the 0.01 μm limit is because of the discovery of ultramicrobacteria as small as 0.2 μm across.
Robotic advocates consider that humans represent a significant source of contamination for the samples, and that a BSL-4 facility with robotic systems is the best way forward.
- Astronomy:Astrobiology – Science concerned with life in the universe
- Astronomy:Mars sample-return mission – Mars mission to collect rock and dust samples
- Earth:Planetary geology – The geology of astronomical objects apparently in orbit around stellar objects
- Engineering:Safety engineering – Engineering discipline which assures that engineered systems provide acceptable levels of safety
- Biology:Select agent – Controlled biological agents in the United States
- Wikisource:Outer Space Treaty of 1967#Article IX
- Full text of the Outer Space Treaty Treaty on Principles Governing the Activities of States in the Exploration and Use of Outer Space, including the Moon and Other Celestial Bodies - See Article IX
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- A Draft Test Protocol for Detecting Possible Biohazards in Martian Samples Returned to Earth
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- 2010 Mars Sample Return Orbiter decadal survey
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- Allen, Carlton; Allton, Judith; Lofgren, Gary; Righter, Kevin; Zolensky, Michael (2011). "Curating NASA's extraterrestrial samples—Past, present, and future". Geochemistry 71 (1): 1–20. doi:10.1016/j.chemer.2010.12.003. Bibcode: 2011ChEG...71....1A.
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- Transport to Curation Facility. Euro-CARES. Andrea Longobardo, Fabrizio Dirri, Ernesto Palomba. 31 October 2016.
- EURO EURO-CARES Extraterrestrial Sample Curation Facility: Architecture as an enabler of science. (PDF) Aurore Hutzler, Emre Kilic, Allan Bennett, Ludovic Ferrière. 47th International Conference on Environmental Systems, 16–20 July 2017, Charleston, South Carolina. Document ICES-2017-323.
- EURO-CARES. European Curation of Astromaterials Returned from Exploration of Space. Accessed: 25 September 2018.
- Ronald Atlas (2002). "Mars Sample Return Receiving Facility". NASA. http://www.lpi.usra.edu/pss/presentations/200803/04-Atlas-PPSonMSR.pdf.
- Ronald Atlas (2008). "Mars Sample Return Receiving Facility". NASA. https://www.lpi.usra.edu/pss/presentations/200803/04-Atlas-PPSonMSR.pdf.
- Assessment of Planetary Protection Requirements for Mars Sample Return Missions (Report). National Research Council. 2009. p. 59.
- Mars Sample Return: Issues and Recommendations (Planetary Protection Office Summary) Task Group on Issues in Sample Return. National Academies Press, Washington, DC (1997)
- Mobile/Modular BSL-4 Facilities for Meeting Restricted Earth Return Containment Requirements. M. J. Calaway, F. M. McCubbin, J. H. Allton, R. A. Zeigler, and L. F. Pace. (PDF) NASA. 2017.
- European Science Foundation - Mars Sample Return backward contamination - Strategic advice and requirements
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