Chemistry:PSB-SB-1202
From HandWiki
Short description: Chemical compound
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| Formula | C23H26O4 |
| Molar mass | 366.45 g·mol−1 |
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PSB-SB-1202 is a coumarin derivative which is an agonist at the cannabinoid receptors CB1 and CB2, with a CB1 Ki of 32nM and a CB2 Ki of 49nM.[1] It is also a weak antagonist at the related receptor GPR55, with an IC50 of 6350nM, but has no significant affinity for GPR18.[2]
See also
References
- ↑ "7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists". Journal of Medicinal Chemistry 55 (18): 7967–77. September 2012. doi:10.1021/jm3008213. PMID 22916707.
- ↑ "Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold". Journal of Medicinal Chemistry 56 (11): 4798–810. June 2013. doi:10.1021/jm4005175. PMID 23679955.
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