Chemistry:List of combined sex-hormonal preparations

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This is a list of known combined sex-hormonal formulations. Brand names and developmental code names are in parentheses.


Androgens

Injection

Marketed

  • Nandrolone decanoate/nandrolone phenylpropionate (Dinandrol)
  • Testosterone propionate/testosterone isocaproate/testosterone caproate (Androteston PP)[1]
  • Testosterone propionate/testosterone enanthate/testosterone undecylenate (Durasteron)
  • Testosterone propionate/testosterone enanthate (Testoviron Depot)
  • Testosterone propionate/testosterone ketolaurate (Testosid Depot)
  • Testosterone propionate/testosterone phenylpropionate/testosterone isocaproate (Sustanon 100)
  • Testosterone propionate/testosterone phenylpropionate/testosterone isocaproate/testosterone caproate (Omnadren 250)
  • Testosterone propionate/testosterone phenylpropionate/testosterone isocaproate/testosterone decanoate (Sustanon 250)
  • Testosterone propionate/testosterone valerate/testosterone undecylenate (Triolandren)
  • Testosterone propionate/testosterone cypionate/prasterone (Sten)

Veterinary

Marketed

  • Boldenone acetate/boldenone cypionate/boldenone propionate/boldenone undecylenate (Equilon 100)
  • Testosterone acetate/testosterone undecanoate/testosterone valerate (Deposterona)

Estrogens

Oral

Marketed

Injection

Marketed

  • Estradiol benzoate/estradiol phenylpropionate (Dimenformon Prolongatum)

Never marketed

  • Estradiol/estradiol enanthate

Progestogens

Injection

Marketed

  • Progesterone/hydroxyprogesterone heptanoate/α-tocopherol palmitate (Tocogestan)

Androgens and estrogens

Oral

Marketed

  • Chlorotrianisene/methyltestosterone (Tace mit Androgen)[1]
  • Conjugated estrogens/methyltestosterone (Premarin with Methyltestosterone)
  • Dienestrol/methyltestosterone (Estan, Lucidon)
  • Dienestrol diacetate/methyltestosterone (Farmatest)
  • Diethylstilbestrol/methyltestosterone (Tylosterone)
  • Esterified estrogens/methyltestosterone (Covaryx, Eemt, Essian, Estratest, Menogen, Syntest)
  • Ethinylestradiol/methyltestosterone (Climatone, Dumone, Duotrone, Estandron, Femandren, Femovirin, Gynetone, Lynandron, Mepilin, Mixogen, Primodian)[1][2]
  • Methylestradiol/methyltestosterone (Klimanosid)[2]
  • Methylestradiol/methyltestosterone/reserpine (Klimanosid R)[1]

Injection

Marketed

  • Estradiol benzoate/testosterone propionate (Bothermon)
  • Estradiol benzoate/estradiol dienanthate/testosterone enanthate benzilic acid hydrazone (Climacteron, Lactimex, Lactostat)
  • Estradiol benzoate/estradiol phenylpropionate/testosterone propionate/testosterone phenylpropionate/testosterone isocaproate (Estandron Prolongatum, Lynandron Prolongatum, Mixogen [Injection])
  • Estradiol benzoate/testosterone isobutyrate (Femandren M, Folivirin)
  • Estradiol butyrylacetate/testosterone ketolaurate/reserpine (Klimanosid R-Depot)
  • Estradiol cypionate/testosterone cypionate (Depo-Testadiol, Femovirin)
  • Estradiol cypionate/testosterone enanthate (Supligol)
  • Estradiol valerate/prasterone enanthate (Binodian Depot, Cidodian Depot, Gynodian Depot, Klimax, Supligol NF)
  • Estradiol valerate/testosterone enanthate (Deladumone, Despamen, Ditate, Ditate-DS, Gravignost, Primodian Depot, Valertest)

Veterinary

Marketed

  • Diethylstilbestrol/methyltestosterone (Maxymin, Tylosterone)
  • Diethylstilbestrol/testosterone (Rapigain)
  • Estradiol benzoate/estradiol enanthate/testosterone enanthate (Uni-Bol)
  • Estradiol benzoate/testosterone propionate (Component E-H, Implix BF, Progro H, Synovex H)
  • Ethinylestradiol/methyltestosterone (Taril)

Estrogens and progestogens

Oral

Marketed

In birth control pills:

  • Drospirenone/estetrol (Nextstellis, Drovelis, Lydisilka)
  • Estradiol/nomegestrol acetate (Naemis, Zoely)
  • Estradiol valerate/cyproterone acetate (Femilar)
  • Estradiol valerate/dienogest (Natazia, Qlaira)
  • Ethinylestradiol/chlormadinone acetate (Belara)[3]
  • Ethinylestradiol/cyproterone acetate (Diane, Diane-35)
  • Ethinylestradiol/desogestrel (Alenvona, Apri,[4] Azurette,[5] Bekyree,[6] Bimizza,[7] Caziant,[8] Cesia,[9] Cimizt,[10] Cyclessa,[11] Cyred,[12] Denise, Desogen,[13] Desirett, Emoquette,[14] Enskyce,[15] Gedarel, Gracial, Isibloom,[16] Juleber,[17] Kalliga, Kariva,[18] Kimidess,[19] Laurina, Linessa, Marvelon,[20][21][22] Mercilon,[23][24] Mircette,[25] Mirvala, Novynette, Ortho-Cept,[26] Pimtrea,[27] Reclipsen,[28] Regulon, Simliya,[29] Solia, Velivet,[30] Viorele,[31] Volnea[32])
  • Ethinylestradiol/dienogest (Valette)
  • Ethinylestradiol/dimethisterone (Oracon)
  • Ethinylestradiol/drospirenone (Yasmin, Yasminelle, Yaz)
  • Ethinylestradiol/drospirenone/levomefolic acid (Beyaz, Safyral)
  • Ethinylestradiol/etynodiol diacetate (Demulen)
  • Ethinylestradiol/gestodene (Femodene, Femodette, Gynera, Harmonet, Meliane, Minesse, Minulet)
  • Ethinylestradiol/levonorgestrel (Amethyst, Aviane, Balcoltra, Falmina, Levlen, Lillow, Orsythia, Vienva)
  • Ethinylestradiol/levonorgestrel/bisglycinate
  • Ethinylestradiol/levonorgestrel/ferrous fumarate
  • Ethinylestradiol/lynestrenol (Lyndiol)
  • Ethinylestradiol/medroxyprogesterone acetate (Gianda, Provest)
  • Ethinylestradiol/megestrol acetate (Nuvacon, Volidan)
  • Ethinylestradiol/norethisterone (Brevicon, Norinyl 1+35, Ortho-Novum 7/7/7, Taytulla, Tri-Norinyl, Zenchent)
  • Ethinylestradiol/norethisterone/ferrous fumarate (Blisovi 24 FE, Estrostep Fe, Femcon FE, Kaitlib FE, Lo Minastrin Fe, Loestrin 24 Fe, Microgestin 24 FE)
  • Ethinylestradiol/norethisterone acetate (FemHRT)
  • Ethinylestradiol/norethisterone acetate/ferrous fumarate
  • Ethinylestradiol/norgestimate (Ortho Tri-Cyclen, Sprintec)
  • Ethinylestradiol/norgestrel (Ovral)
  • Ethinylestradiol/norgestrienone (Miniplanor, Planor)
  • Ethinylestradiol/quingestanol acetate (Riglovis)
  • Ethinylestradiol sulfonate/norethisterone acetate (Deposiston)
  • Mestranol/anagestone acetate (Neo-Novum)
  • Mestranol/chlormadinone acetate (C-Quens, Lutedion)
  • Mestranol/etynodiol diacetate (Ovulen)
  • Mestranol/hydroxyprogesterone acetate (Hormolidin)
  • Mestranol/lynestrenol (Lyndiol)
  • Mestranol/norethisterone (Norethin, Noriday, Norinyl, Norquen, Ortho-Novum)
  • Mestranol/noretynodrel (Enavid, Enovid)
  • Quinestrol/etynodiol diacetate (Soluna)
  • Quinestrol/levonorgestrel (Yuèkětíng, Àiyuè)
  • Quinestrol/norgestrel (Compound Norgestrel)
  • Quinestrol/quingestanol acetate (Unovis)

For menopausal hormone therapy and/or gynecological disorders:

  • Conjugated estrogens/medrogestone (Presomen)
  • Conjugated estrogens/medroxyprogesterone acetate (Prempro, Premphase)
  • Conjugated estrogens/norgestrel (Prempak-C)
  • Estradiol/drospirenone (Angeliq)
  • Estradiol/dydrogesterone (Femoston)
  • Estradiol/gestodene (Avaden, Avadene)
  • Estradiol/levonorgestrel
  • Estradiol/medroxyprogesterone acetate (Indivina, Tridestra)
  • Estradiol/norethisterone acetate (Activella, Activelle, Cliane, Estalis, Eviana, Evorel, Kliogest, Novofem)
  • Estradiol/norgestimate (Prefest)
  • Estradiol/progesterone (Bijuva)
  • Estradiol/trimegestone (Lovelle, Totelle)
  • Estradiol valerate/cyproterone acetate (Climen, Climen 28)
  • Estradiol valerate/estriol/levonorgestrel (CycloÖstrogynal)
  • Estradiol valerate/levonorgestrel (Cyclo-Progynova N)
  • Estradiol valerate/medroxyprogesterone acetate (Dilena, Divina, Divitren, Farludiol, Indivina, Sisare)
  • Estradiol valerate/norethisterone (Climagest, Climesse)
  • Estradiol valerate/norethisterone acetate (Cliovelle, Norestin, Trisequens)
  • Estradiol valerate/norgestrel (Cyclacur, Cyclocur, Cyclo-Progynova, Postoval, Progyluton)
  • Ethinylestradiol/ethisterone (Amenorone, Di-Pro, Duosterone, Menstrogen, Oracecron, Orasecron)[2][1]
  • Mestranol/noretynodrel (Enovid)

Never or not yet marketed

In birth control pills:

  • Estradiol/norethisterone (Netagen, Netagen 403)

Transdermal

Marketed

In contraceptive patches:

  • Ethinylestradiol/norelgestromin (Evra, Ortho Evra, Xulane)

For menopausal hormone therapy:

  • Estradiol/levonorgestrel (Climara Pro)
  • Estradiol/norethisterone acetate (CombiPatch)

Vaginal

Marketed

In contraceptive vaginal rings:

  • Ethinylestradiol/etonogestrel (Circlet, NuvaRing)
  • Segesterone acetate/ethinylestradiol (Annovera)

Injection

Marketed

In combined injectable contraceptives:

  • Estradiol/megestrol acetate (Mego-E, Chinese Injectable No. 2)
  • Estradiol benzoate/estradiol valerate/hydroxyprogesterone caproate (Sin-Ol)
  • Estradiol benzoate butyrate/algestone acetophenide (Redimen, Soluna, Unijab)
  • Estradiol cypionate/hydroxyprogesterone caproate (Sinbios)
  • Estradiol cypionate/medroxyprogesterone acetate (Cyclo-Provera, Cyclofem, Lunelle)
  • Estradiol enanthate/algestone acetophenide (Anafertin, Deladroxate, Perlutan, Topasel, Yectames)
  • Estradiol valerate/hydroxyprogesterone caproate (Chinese Injectable No. 1)
  • Estradiol valerate/norethisterone enanthate (Mesigyna, Mesygest)

For menopausal hormone therapy, gynecological disorders, habitual abortion, and other indications:

  • Estradiol/progesterone (Juvenum)
  • Estradiol benzoate/hydroxyprogesterone caproate (Primosiston)
  • Estradiol benzoate/progesterone (Duogynon, Sistocyclin)
  • Estradiol dipropionate/hydroxyprogesterone caproate (EP Hormone Depot)
  • Estradiol hemisuccinate/progesterone (Hosterona)
  • Estradiol pivalate/progesterone (Estrotate with Progesterone)
  • Estradiol valerate/hydroxyprogesterone caproate (Gravibinan, Gravibinon)
  • Estrone/progesterone (Synergon)

Never marketed

In combined injectable contraceptives:

  • Estradiol/progesterone (in microspheres and macrocrystalline aqueous suspension)
  • Estradiol undecylate/norethisterone enanthate
  • Estradiol valerate/megestrol acetate
  • Estradiol valerate/methenmadinone caproate (Lutofollin)
  • Polyestradiol phosphate/medroxyprogesterone acetate
  • Additional preparations listed at Combined injectable birth control § Research

For other indications:

  • Estradiol valerate/gestonorone caproate (SH-834, SH-8.0834)

Veterinary

Marketed

  • Estradiol benzoate/progesterone (Component E-S, Implix BM, Synovex C, Synovex S)
  • Estradiol valerate/norgestomet (Syncro-Mate-B)

Androgens and progestogens

Oral

Marketed

  • Methyltestosterone/ethisterone (Androgeston)[1]

Injection

Marketed

Veterinary

Marketed

  • Danazol/megestrol acetate (Dogalact)
  • Nandrolone decanoate/methandriol dipropionate (Filybol, Tribolin)
  • Nandrolone phenylpropionate/methandriol dipropionate (RWR)

Estrogens, progestogens, and androgens

Oral

Marketed

  • Methylestradiol/normethandrone (Ginecosid, Ginecoside, Mediol, Renodiol)

Not yet marketed

  • Ethinylestradiol/drospirenone/prasterone

Sublingual

Marketed

  • Estradiol/progesterone/methyltestosterone (Trihormonal)[1]
  • Ethinylestradiol/ethisterone/methyltestosterone (Trinestryl, Trimone Sublets)[1]

Injection

Marketed

  • Estradiol benzoate/progesterone/methandriol dipropionate (Progestandron)
  • Estradiol benzoate/progesterone/testosterone propionate (Lukestra, Steratrin, Trihormonal, Trinestryl)[1][2][36]
  • Estradiol benzoate/estradiol valerate/norethisterone acetate/testosterone enanthate (Ablacton)
  • Estradiol dibutyrate/hydroxyprogesterone heptanoate/testosterone caproate (Triormon Depositum)
  • Estradiol diundecylate/hydroxyprogesterone heptanoate/testosterone cyclohexylpropionate (Trioestrine Retard)
  • Estradiol hexahydrobenzoate/hydroxyprogesterone caproate/testosterone hexahydrobenzoate (Trinestril AP)
  • Estrone/progesterone/testosterone (Tristeron, Tristerone)[36]

Never marketed

  • Estrapronicate/hydroxyprogesterone heptanoate/nandrolone undecanoate (Trophobolene, Trophoboline)

Veterinary

Marketed

  • Estradiol/trenbolone acetate (Component, Compudose-G, Progro TE-H, Revalor, Synovex)
  • Estradiol benzoate/trenbolone acetate (Synovex Choice, Synovex One, Synovex Plus, Synovex with Trenbolone Acetate)

Miscellaneous

Oral

Marketed

  • Conjugated estrogens/bazedoxifene (Duavee)

Never marketed

  • Esterified estrogens/raloxifene
  • Estradiol/raloxifene

Transdermal

Marketed

  • Estradiol benzoate/prednisolone/salicylic acid (Alpicort E, Alpicort F, Alpicort Plus)

Vaginal

Marketed

  • Estradiol benzoate/gentamicin/hydrocortisone/nystatin (Cridermol Fem, Ginabiot, Ginecovan)
  • Estradiol benzoate/monalazone (Malun-25)

Mixed

Marketed

  • Goserelin/bicalutamide (ZolaCos CP)
  • Leuprorelin/norethisterone acetate (Lupaneta Pack)

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Hans Hermann Julius Hager; Walther Kern; Paul Heinz List; Hermann Josef Roth (29 July 2013). Hagers Handbuch der Pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Ärzte und Medizinalbeamte: Wirkstoffgruppen II Chemikalien und Drogen (A-AL). Springer-Verlag. pp. 143, 185–187. ISBN 978-3-662-25655-8. https://books.google.com/books?id=a2a0BgAAQBAJ&pg=PA185. Retrieved 3 June 2019. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Georg Arends; Heinrich Zörnig; Hermann Hager; Georg Frerichs, Walther Kern (14 December 2013). Hagers Handbuch der pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Drogisten, Ärzte u. Medizinalbeamte. Springer-Verlag. pp. 1163–1164. ISBN 978-3-662-36329-4. https://books.google.com/books?id=8bLwBgAAQBAJ&pg=PA1163. Retrieved 3 June 2019. 
  3. ↑ "Archived copy". https://www.ema.europa.eu/documents/psusa/chlormadinone-acetate/ethinylestradiol-list-nationally-authorised-medicinal-products-psusa/00000679/202111_en.pdf. 
  4. ↑ "Apri 28 Day- desogestrel and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a9e08f9b-9862-4c2c-8302-53dc82d85126. 
  5. ↑ "Azurette- desogestrel/ethinyl estradiol and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bff09a7b-aea6-460b-a263-44576e00f510. 
  6. ↑ "Bekyree- desogestrel and ethinyl estradiol and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b9051bb5-21d0-4c76-9b70-c9cd89e67eb0. 
  7. ↑ "Bimizza 150 microgram/20 microgram Tablets - Summary of Product Characteristics (SmPC)". https://www.medicines.org.uk/emc/product/9567/smpc. 
  8. ↑ "Caziant Triphasic Regimen- desogestrel and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4e61bbb8-9b1b-4583-a7ad-1985b6d4de90. 
  9. ↑ "Cesia- desogestrel and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fed687f4-1ffa-49ec-92c9-4d09de17a833. 
  10. ↑ "Cimizt 150 microgram/30 microgram Tablets - Summary of Product Characteristics (SmPC)". https://www.medicines.org.uk/emc/product/9568/smpc. 
  11. ↑ "Cyclessa Tablets (desogestrel and ethinyl estradiol tablets USP)". https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=311686. 
  12. ↑ "Cyred EQ- desogestrel and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2417aee4-6838-4ea6-8e0d-3144f522310c. 
  13. ↑ "Desogen Tablets". https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=276234. 
  14. ↑ "Emoquette- desogestrel and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad604496-2df0-429e-b0da-12c6c38e61a5. 
  15. ↑ "Enskyce- desogestrel and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=19dd4b23-b6e0-483a-97a7-fbabd201b1c2. 
  16. ↑ "Isibloom- desogestrel and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7dbc4cdf-4ce2-5c66-343f-df381f56692a. 
  17. ↑ "Juleber- desogestrel and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de9a2d1b-15f6-453f-b36b-1c2a43c4918d. 
  18. ↑ "Kariva- desogestrel/ethinyl estradiol and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7b11e11f-6977-4109-b9bd-a066e5d1278a. 
  19. ↑ "Kimidess (Desogestrel and Ethinyl Estradiol Tablets, USP and Ethinyl Estradiol Tablets, USP), 0.15 mg/0.02 mg and 0.01 mg". https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=438314. 
  20. ↑ "Marvelon Tablets - Summary of Product Characteristics (SmPC)". https://www.medicines.org.uk/emc/product/1359/smpc. 
  21. ↑ "Marvelon desogestrel / ethinylestradiol 28 tablets". https://tga-search.clients.funnelback.com/s/search.html?collection=tga-artg&profile=record&meta_i=42894. 
  22. ↑ "Marvelon Product Information". https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-06525-3. 
  23. ↑ "Mercilon- desogestrel, ethinyl estradiol tablet". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7cb97fc9-59d2-3271-e053-2a91aa0afa5c. 
  24. ↑ "Mercilon Tablets - Summary of Product Characteristics (SmPC)". https://www.medicines.org.uk/emc/product/1360/smpc. 
  25. ↑ "Mircette- desogestrel/ethinyl estradiol and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a39bb616-9e84-4142-8450-824f88528906. 
  26. ↑ "Ortho-Cept Tablets (Desogestrel And Ethinyl Estradiol)". https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=336921. 
  27. ↑ "Pimtrea- desogestrel/ethinyl estradiol and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b716fd2a-b186-447a-85bd-6302284d14e5. 
  28. ↑ "Reclipsen 28 Day- desogestrel and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a1e00bc6-7487-4057-9dcc-d0e2327d1d12. 
  29. ↑ "Simliya- desogestrel and ethinyl estradiol and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4161f614-6e55-4114-87f7-19bb77f6b09b. 
  30. ↑ "Velivet Triphasic Regimen- desogestrel and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a3ce5125-62ba-4983-93f0-91f254271605. 
  31. ↑ "Viorele- desogestrel and ethinyl estradiol and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=39988aa6-8f68-40e8-9bdd-c40a3bdaad61. 
  32. ↑ "Volnea- desogestrel and ethinyl estradiol kit". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d7f3a118-4a1a-786e-c1db-01a0c2f2189d. 
  33. ↑ Josef Kimmig (14 March 2013). Therapie der Haut- und Geschlechtskrankheiten. Springer-Verlag. pp. 508–. ISBN 978-3-642-94850-3. https://books.google.com/books?id=txrUBgAAQBAJ&pg=PA508. Retrieved 3 June 2019. 
  34. ↑ "Spezialitäten". Klinische Wochenschrift 30 (15–16): 367. 1952. doi:10.1007/BF01472052. ISSN 0023-2173. 
  35. ↑ Archived copy
  36. ↑ 36.0 36.1 Hormone und Psyche die Endokrinologie des Alternden Menschen: Fünftes Symposion der Deutschen Gesellschaft für Endokrinologie Freiburg (Breisgau), den 7. bis 9. März 1957. Springer-Verlag. 9 March 2013. pp. 55–. ISBN 978-3-642-87014-9. https://books.google.com/books?id=4NKEBwAAQBAJ&pg=PA55. Retrieved 9 June 2019. 

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See also
Androgen receptor modulators
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