Chemistry:Haloprogesterone
 | |
| Clinical data | |
|---|---|
| Trade names | Prohalone |
| Other names | Aloprogesterone; 6α-Fluoro-17α-bromoprogesterone; 6α-Fluoro-17α-bromopregn-4-ene-3,20-dione |
| Routes of administration | By mouth |
| Drug class | Progestogen; Progestin |
| ATC code |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C21H28BrFO2 |
| Molar mass | 411.355 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Haloprogesterone, sold under the brand name Prohalone, is a progestin medication which was previously marketed by Ayerst but is now no longer available.[1][2][3]
Chemistry
Haloprogesterone, also known as 6α-fluoro-17α-bromoprogesterone or as 6α-fluoro-17α-bromopregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a halogenated derivative of progesterone.[1] It is specifically a derivative of 17α-bromoprogesterone and is similar structurally to medrogestone (6-dehydro-6,17α-dimethylprogesterone), medroxyprogesterone acetate (6α-methyl-17α-acetoxyprogesterone), and various other progestins derived from progesterone.[1]
Synthesis
Chemical syntheses of haloprogesterone have been published.[4]
History
Haloprogesterone was synthesized in 1960 and was introduced for medical use by 1961.[1][5][6]
Society and culture
Generic names
Haloprogesterone is the generic name of the drug and its INN and USAN.[1][3]
Brand names
Haloprogesterone was marketed under the brand name Prohalone.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 620–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA620.
- ↑ American Pharmaceutical Association (1976). APhA drug names: an index of drug names. American Pharmaceutical Association. ISBN 9780917330094. https://books.google.com/books?id=IwdtAAAAMAAJ.
- ↑ 3.0 3.1 United States Adopted Names (USAN).. United States Pharmacopeial Convention.. 1968. p. 715. https://books.google.com/books?id=xvlsAAAAMAAJ.
- ↑ Die Gestagene. Springer-Verlag. 27 November 2013. pp. 9–10. ISBN 978-3-642-99941-3. https://books.google.com/books?id=t8GpBgAAQBAJ&pg=PA9.
- ↑ Official Gazette of the United States Patent Office. The Office. 1961. p. 74. https://books.google.com/books?id=48QhHLTR3LMC.
- ↑ The Journal of New Drugs. 1962. p. 127. https://books.google.com/books?id=10FPAQAAIAAJ.
 |  |
