Chemistry:Cyheptamide
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Cyheptamide was a investigational new drug that was developed by Ayerst Research Laboratories in the 1960s and was evaluated as an anticonvulsant.[1]
Cyheptamide undergoes significant metabolic transformation in both animals and humans, primarily through hydroxylation pathways.[2]
Cyheptamide exhibits moderate acute toxicity in animal models, with species-specific variations in lethal dose values.[3]
Another agent that is creditworthy of consideration is called SGB-017 [183904-41-8].[4]
See also
References
- ↑ "Cyheptamide". NCATS. https://drugs.ncats.io/drug/6R22P8K61P.
- ↑ "Metabolism of the anticonvulsant 10,11-dihydro-5H-dibenzo(a,d)cycloheptene-5-carboxamide. I. Metabolic fate of (14C)cyheptamide in animals and man". Biochemical Pharmacology 20 (9): 2327–2338. September 1971. doi:10.1016/0006-2952(71)90232-2. PMID 5163146.
- ↑ "Toxicological study of cyheptamide: 10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-carboxamide (BS 7029)". Archives Internationales de Pharmacodynamie et de Therapie 188 (1): 79–85. November 1970. PMID 5485105.
- ↑ "SGB‐017 (ADCI): A Novel Anticonvulsant with a Dual Mechanism of Action". CNS Drug Reviews 5 (4): 365–378. December 1999. doi:10.1111/j.1527-3458.1999.tb00111.x. https://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.1999.tb00111.x.
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