Chemistry:Tampramine
From HandWiki
Short description: Chemical compound
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| Routes of administration | Oral |
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| Formula | C23H24N4 |
| Molar mass | 356.473 g·mol−1 |
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Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed.[1][2] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors.[1] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans.[2]
See also
References
- ↑ 1.0 1.1 "Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake". Biochemical Pharmacology 33 (19): 3001–5. October 1984. doi:10.1016/0006-2952(84)90600-2. PMID 6548381.
- ↑ 2.0 2.1 "Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate". Psychopharmacology 87 (3): 283–5. 1985. doi:10.1007/BF00432708. PMID 3936083.
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