Chemistry:Metharbital
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Short description: Barbiturate anticonvulsant medication
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| Other names | Endiemal, metharbitone, methobarbitone[1] |
| Routes of administration | By mouth (tablets) |
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| Formula | C9H14N2O3 |
| Molar mass | 198.222 g·mol−1 |
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Metharbital was patented in 1905 by Emil Fischer working for Merck.[2] It was marketed as Gemonil by Abbott Laboratories. It is a barbiturate anticonvulsant, used in the treatment of epilepsy.[3][4] It has similar properties to phenobarbital.
History
- 1952 Gemonil was introduced by Abbott Laboratories.
- 1990 Abbott stopped marketing.
Synthesis
Metharbital can be synthesized from 2,2-diethylmalonic acid and O-methylisourea.[5][6][2]
References
- ↑ "Metharbital". The Comparative Toxicogenomics Database. http://ctdbase.org/detail.go?type=chem&acc=C084822.
- ↑ 2.0 2.1 Fischer E, "Trisubstituted barbituric acids and process of making them.", US patent 782742, issued 14 February 1905, assigned to E. Merck
- ↑ The Treatment of Epilepsy (2nd ed.). Blackwell. 2004. ISBN 0-632-06046-8.
- ↑ The Medical Treatment of Epilepsy. Marcel Dekker. 1991. ISBN 0-8247-8549-5.
- ↑ "The characterization of the trialkylbarbiturates". Journal of the American Pharmaceutical Association 38 (6): 352–5. June 1949. doi:10.1002/jps.3030380619. PMID 18151714.
- ↑ "Preparation and Characterization by Alkaline Methanolysis of 5,5-Diethyl-4-(tetraacetyl-β-D-glucosyloxy)-2,6(1,5)-pyrimidinedione". Journal of the American Chemical Society 75 (8): 1881–1883. 1953. doi:10.1021/ja01104a030.
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