Chemistry:20α-Dihydrodydrogesterone
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Short description: Chemical compound
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| Other names | 20α-DHD; 20α-Hydroxydydrogesterone; 20(S)-Hydroxy-9β,10α-pregna-4,6-dien-3-one |
| Drug class | Progestin; Progestogen |
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| Elimination half-life | 14–17 hours[1] |
| Excretion | Urine (mainly as glucuronide conjugates) |
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| Chemical and physical data | |
| Formula | C21H30O2 |
| Molar mass | 314.469 g·mol−1 |
| 3D model (JSmol) | |
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20α-Dihydrodydrogesterone (20α-DHD), also known as 20α-hydroxydydrogesterone, as well as 20(S)-hydroxy-9β,10α-pregna-4,6-dien-3-one, is a progestin and the major active metabolite of dydrogesterone.[2][1][3] It appears that dydrogesterone is a prodrug of 20α-DHD, as it is largely transformed into this metabolite when given orally in humans.[3] 20α-DHD has progestogenic activity similarly to dydrogesterone, but is far less potent in comparison.[3]
See also
References
- ↑ 1.0 1.1 "Progestogens in menopausal hormone therapy". Przeglad Menopauzalny = Menopause Review 14 (2): 134–143. June 2015. doi:10.5114/pm.2015.52154. PMID 26327902.
- ↑ "Dydrogesterone metabolism in human liver by aldo-keto reductases and cytochrome P450 enzymes". Xenobiotica; the Fate of Foreign Compounds in Biological Systems 46 (10): 868–874. October 2016. doi:10.3109/00498254.2015.1134852. PMID 26796435.
- ↑ 3.0 3.1 3.2 "Selectivity and potency of the retroprogesterone dydrogesterone in vitro". Steroids 76 (6): 607–615. May 2011. doi:10.1016/j.steroids.2011.02.043. PMID 21376746.
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