Chemistry:ORG-2058
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Short description: Chemical compound
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| Other names | 16α-Ethyl-21-hydroxy-19-norprogesterone; 16α-Ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione |
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| Formula | C22H32O3 |
| Molar mass | 344.495 g·mol−1 |
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ORG-2058, also known as 16α-ethyl-21-hydroxy-19-norprogesterone, is a progestin of the 19-norprogesterone group which was never marketed.[1][2] It has high affinity for the progesterone receptor (775% of that of progesterone) and has been used in scientific research to study the role of the progesterone receptor in the body.[2] The drug has no affinity for the estrogen receptor or the glucocorticoid receptor (less than 0.2% of the affinities of estradiol and dexamethasone, respectively)[3] and has slight affinity for the mineralocorticoid receptor, but less than that of progesterone.[4]
See also
References
- ↑ Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. 2001. p. 2350. ISBN 978-3-527-30247-5. https://books.google.com/books?id=zmpqAAAAMAAJ.
- ↑ 2.0 2.1 "Characterization of the progesterone receptor of rabbit uterus with the synthetic progestin 16α-ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione". Biochimica et Biophysica Acta (BBA) - General Subjects 540 (3): 500–517. 1978. doi:10.1016/0304-4165(78)90180-0. ISSN 0304-4165.
- ↑ "Receptor binding of allylestrenol, a progestagen of the 19-nortestosterone series without androgenic properties". Journal of Steroid Biochemistry 23 (2): 165–168. August 1985. doi:10.1016/0022-4731(85)90232-8. PMID 3928974.
- ↑ Steroid receptors and the management of cancer. CRC Press. 1979. ISBN 978-0-8493-5477-9. https://books.google.com/books?id=k8xrAAAAMAAJ. "Org 2058 competed slightly, but less than progesterone, for mineralocorticoid binding."
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