Chemistry:Edogestrone
From HandWiki
Short description: Chemical compound
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| Other names | Edogesterone; PH-218; 17α-Acetoxy-3,3-ethylenedioxy-6-methylpregn-5-en-20-one |
| Drug class | Progestogen; Progestogen ester |
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| Formula | C26H38O5 |
| Molar mass | 430.585 g·mol−1 |
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Edogestrone (INN, BAN) (developmental code name PH-218), or edogesterone, also known as 17α-acetoxy-3,3-ethylenedioxy-6-methylpregn-5-en-20-one, is a steroidal progestin and antiandrogen of the 17α-hydroxyprogesterone group which was synthesized in 1964 but was never marketed.[1][2] Similarly to the structurally related steroid cyproterone acetate, edogestrone binds directly to the androgen receptor and antagonizes it, displacing androgens like testosterone from the receptor, though not as potently as cyproterone acetate.[3] The drug has also been found to suppress androgen production, likely via progesterone receptor activation-mediated antigonadotropic activity.[4]
See also
- Steroidal antiandrogen
- List of progestogens
- List of steroidal antiandrogens
- List of progestogen esters
References
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 478–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA478.
- ↑ "Biologic and biochemical effects of anti-androgens on rat ventral prostate". Acta Endocrinologica 75 (2): 385–397. February 1974. doi:10.1530/acta.0.0750385. PMID 4406552.
- ↑ Male accessory sex glands: biology and pathology. Elsevier/North-Holland Biomedical Press. 1 January 1980. p. 500. ISBN 9780444801678. https://books.google.com/books?id=YjZsAAAAMAAJ.
- ↑ The Treatment of Prostatic Hypertrophy and Neoplasia. Springer Science & Business Media. 9 March 2013. pp. 39–. ISBN 978-94-015-7190-6. https://books.google.com/books?id=Nc8hBQAAQBAJ&pg=PA39. "Geller has also demonstrated significant decreases in plasma or urine testosterone glucuronide levels following the administration of three other anti-androgens. These include Delalutin, Chlormadinone acetate, and PH-218. It would appear that decreased androgen production is a property shared by all anti-androgens to date."
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