Chemistry:Mecigestone
From HandWiki
Short description: Chemical compound
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| Other names | Pentarane B; 6α-Methyl-16α,17α-cyclohexanoprogesterone |
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| Formula | C26H38O2 |
| Molar mass | 382.588 g·mol−1 |
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Mecigestone, also known as pentarane B, as well as 6α-methyl-16α,17α-cyclohexanoprogesterone, 6α-methylcyclohexano[1',2';16,17]pregn-4-ene-3,20-dione, or 17α-acetyl-6α-methyl-16β,24-cyclo-21-norchol-4-en-3-one, is a steroidal progestin that was developed by the Zelinskii Institute of Organic Chemistry of the Russian Academy of Sciences and has been proposed for clinical use as a progestogen but has not been marketed.[1][2][3][4][5] It is the 6α-methylated analogue of pentarane A, which is also known as D'6-pentarane or pregna-D'6-pentarane.[5]
See also
References
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 8–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA8.
- ↑ "Molecular docking and 3D-QSAR of 16α,17α-cycloalkanoprogesterone derivatives as ligands of the progesterone receptor". Biochemistry (Moscow) Supplement Series B 8 (2): 168–176. 2014. doi:10.1134/S1990750814020048. ISSN 1990-7508.
- ↑ "Pregna-D'-pentaranes - a new class of active gestagenes". Journal of Steroid Biochemistry 16 (1): 61–67. January 1982. doi:10.1016/0022-4731(82)90144-3. PMID 7062740.
- ↑ "Preparation and Bioavailability Evaluation of Micronized Steroidal Mecigestone Drug Substance". Pharmaceutical Chemistry Journal 49 (10): 706–710. 2016. doi:10.1007/s11094-016-1357-6. ISSN 0091-150X.
- ↑ 5.0 5.1 "Interaction of cycloalkanoprogesterones with mammalian progesterone receptor: binding of pregna-D'-pentaranes in the calf uterine cytosol". Molecular and Cellular Biochemistry 125 (2): 153–161. August 1993. doi:10.1007/BF00936444. PMID 8283970.
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