Chemistry:Tosagestin
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| Other names | ORG-30659; Exogestin; Letogestin;[1] 11-Methylene-δ15-norethisterone; 17α-Ethynyl-11-methylene-19-nor-δ15-testosterone |
| Routes of administration | By mouth |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C21H24O2 |
| Molar mass | 308.421 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Tosagestin (INN, USAN) (developmental code name ORG-30659), also known as 11-methylene-δ15-norethisterone or 17α-ethynyl-11-methylene-19-nor-δ15-testosterone, is a progestin of the 19-nortestosterone group which was under development by Organon in the United States and Europe as a hormonal contraceptive (in combination with ethinylestradiol) and for the treatment of menopausal symptoms but was never marketed.[2][3][4][5][6]
See also
References
- ↑ Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. 2001. p. 2104. ISBN 978-3-527-30247-5. https://books.google.com/books?id=zmpqAAAAMAAJ.
- ↑ World Health Organization (2013), The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances, p. 95, http://apps.who.int/medicinedocs/collect/medicinedocs/pdf/s4895e/s4895e.pdf
- ↑ "Tosagestin", AdisInsight (Springer Nature Switzerland AG), http://webcache.googleusercontent.com/search?q=cache:GunWHn-ThlcJ:adisinsight.springer.com/drugs/800012399+&cd=1&hl=en&ct=clnk&gl=us, retrieved 12 July 2016
- ↑ "In vitro and in vivo metabolism of the progestagen Org 30659 in several species". Drug Metabolism and Disposition 26 (11): 1102–1112. November 1998. PMID 9806953. http://dmd.aspetjournals.org/content/26/11/1102.long.
- ↑ "Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org 30659 and EE)". Contraception 68 (3): 195–202. September 2003. doi:10.1016/S0010-7824(03)00140-9. PMID 14561540.
- ↑ "Ovarian function during and after treatment with the new progestagen Org 30659". Fertility and Sterility 76 (1): 108–115. July 2001. doi:10.1016/S0015-0282(01)01824-6. PMID 11438328.
 |  |
