Chemistry:Megestrol
Megestrol (INN, BAN) is a progestin of the 17α-hydroxyprogesterone group which was, until recently, never marketed or used clinically.[1][2] It is now used for treatments of disease-related weight loss, endometrial cancer, and breast cancer.[3] Its acylated derivative megestrol acetate is also a progestogen, which, in contrast to megestrol itself, has been extensively used as a pharmaceutical drug.[1][2]
Medical use
As of June 2023, megestrol is being used to treat significant weight loss in HIV/AIDS patients, and as a palliative treatment of endometrial and breast cancers. It can be administered in both tablet and oral suspension forms, with dosages ranging from 100 mg/day to 1600 mg/day depending on the condition being treated.[3]
Synthesis
Megestrol can be synthesized from 6a-methylprogesterone.[4] [5]
See also
References
- ↑ 1.0 1.1 Dictionary of Pharmacological Agents. CRC Press. 1997. p. 1267. ISBN 978-0-412-46630-4. https://books.google.com/books?id=A0THacd46ZsC&pg=PA1267. Retrieved 12 May 2012.
- ↑ 2.0 2.1 Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 641. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA641. Retrieved 28 May 2012.
- ↑ 3.0 3.1 "Megestrol". StatPearls. Treasure Island (FL): StatPearls Publishing. 2024. https://www.ncbi.nlm.nih.gov/books/NBK559205/. Retrieved 2024-04-25.
- ↑ "Steroids. CXVIII.16-Methyl Derivatives of 17α-Hydroxyprogesterone and of Reichstein's Substance "S"". Journal of the American Chemical Society 81 (14): 3712–3716. 1959. doi:10.1021/ja01523a055. Bibcode: 1959JAChS..81.3712R.
- ↑ U.S. Patent 2,891,079
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