Chemistry:Butagest
From HandWiki
Short description: Chemical compound
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| Other names | Buterol; 17α-Acetoxy-3β-butanoyloxy-6-methyl-pregna-4,6-dien-20-one; 17α-Acetoxy-6-methyl-20-oxopregna-4,6-dien-3β-yl butyrate; 6-Methyl-17α-hydroxy-δ6-progesterone 3β-butanoate 17α-acetate |
| Drug class | Progestogen; Progestogen ester |
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| Formula | C28H40O5 |
| Molar mass | 456.623 g·mol−1 |
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Butagest, also known as buterol,[1] as well as 3β-hydroxy-6-methyl-17α-hydroxypregna-4,6-dien-20-one 3β-butanoate 17α-acetate or as 6-methyl-17α-hydroxy-δ6-progesterone 3β-butanoate 17α-acetate, is a steroidal progestin which was developed in Russia for potential clinical use but was never marketed.[2][3][4][5][6] It is a modification of megestrol acetate in which the C3 ketone has been replaced with a C3β butanoyloxy moiety.
See also
References
- ↑ "[Effect of steroid hormones on production of reactive oxygen species in mitochondria]". Biofizika 57 (6): 1014–9. 2012. PMID 23272582.
- ↑ "[Antitumor activity of the new gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one]". Eksp Klin Farmakol 67 (4): 54–6. 2004. PMID 15500049.
- ↑ "[Therapeutic efficacy of novel 17alpha-hydroxyprogesterone derivatives in experimental preterm labor]". Eksp Klin Farmakol 65 (1): 44–5. 2002. PMID 12025785.
- ↑ Fedotcheva, T. A., Semeykin, A. V., Schimanowsky, N. L., & Rzheznikov, V. M. (2004, July). New progestin butagest is a perspective antiproliferative agent and chemosensitizer. In FUNDAMENTAL & CLINICAL PHARMACOLOGY (Vol. 18, pp. 84-84). 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY-BLACKWELL.
- ↑ "[Gestagenic and contraceptive activity of new synthetic progesterone analogs in experimental animals]". Eksp Klin Farmakol 68 (1): 39–41. 2005. PMID 15786963.
- ↑ "[Influence of the structure of synthetic gestagens on their binding to progesteron receptors in the endometrium]". Eksp Klin Farmakol 69 (4): 36–8. 2006. PMID 16995436.
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