Chemistry:Fluticasone
From HandWiki
Short description: Chemical compound
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| Other names | 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione; S-(Fluoromethyl)-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate |
| Routes of administration | Intranasal, inhaled, topical |
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| Bioavailability | 0.51% (Intranasal) |
| Protein binding | 91.0% |
| Metabolism | Intranasal Liver (CYP3A4-mediated) |
| Elimination half-life | 10 hours |
| Excretion | Kidney |
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| Formula | C22H27F3O4S |
| Molar mass | 444.51 g·mol−1 |
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Fluticasone is a manufactured glucocorticoid used to treat nasal symptoms.[1][2][3][4][5] Both the esters, fluticasone propionate (a brand name for which is Flovent) and fluticasone furoate, are also used as topical anti-inflammatories and inhaled corticosteroids, and are used much more commonly in comparison.[3][2][4][6]
It is on the World Health Organization's List of Essential Medicines.[7] In 2021, it was the 23rd most commonly prescribed medication in the United States, with more than 25 million prescriptions,[8][9] although it is also sold over the counter.[10]
See also
- Fluticasone furoate
- Fluticasone furoate/vilanterol
- Fluticasone propionate
- Fluticasone/salmeterol
References
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 574–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA574.
- ↑ 2.0 2.1 Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1337–. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA1337.
- ↑ 3.0 3.1 Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 6 December 2012. pp. 124–. ISBN 978-94-011-4439-1. https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA124.
- ↑ 4.0 4.1 "Fluticasone - FDA prescribing information, side effects and uses". https://www.drugs.com/international/fluticasone.html.
- ↑ Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. 2012. p. 600. ISBN 978-1451153590. https://books.google.com/books?id=ScPvM03B3lUC&pg=PA600.
- ↑ Delmar Nurse's Drug Handbook 2012. Cengage Learning. 2012. p. 748. ISBN 978-1111310653. https://books.google.com/books?id=x-f-kedg9ukC&pg=PA748.
- ↑ World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. 2021. WHO/MHP/HPS/EML/2021.02.
- ↑ "The Top 300 of 2021". https://clincalc.com/DrugStats/Top300Drugs.aspx.
- ↑ "Fluticasone - Drug Usage Statistics". https://clincalc.com/DrugStats/Drugs/Fluticasone.
- ↑ "Fluticasone Nasal Spray". https://www.drugs.com/pro/fluticasone-nasal-spray.html.
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