Chemistry:Riligustilide

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Riligustilide
Riligustilide.svg
Names
IUPAC name
(3S,3′Z,5′aR,6′S,7′aS)-3′-Butylidene-6′-propylspiro[4,5-dihydro-2-benzofuran-3,7′-5,5a,6,7a-tetrahydro-4H-cyclobuta[g][2]benzofuran]-1,1′-dione
Identifiers
3D model (JSmol)
ChemSpider
UNII
Properties
C24H28O4
Molar mass 380.484 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Tracking categories (test):

Riligustilide is a nonsteroidal phytoprogestogen that is found in Ligusticum chuanxiong.[1][2] It is a very weak agonist of the progesterone receptor (EC50 ≈ 81 μM).[1] Another compound in the plant, 3,8-dihydrodiligustilide, is also a phytoprogestogen, but is almost 1,000-fold more potent in comparison (EC50 = 90 nM).[1]

See also

References

  1. ↑ 1.0 1.1 1.2 "Dimeric progestins from rhizomes of Ligusticum chuanxiong". Phytochemistry 67 (7): 728–34. 2006. doi:10.1016/j.phytochem.2006.01.024. PMID 16516938. 
  2. ↑ Ahmed, H.M.M.; Yeh, J.Y.; Lin, W.J.; Forsberg, N.E.; Cheng, W.T.K.; Ou, B.R (2014). "Validation of a luciferase bioassay to detect the progestative activity in gilts whose estrus was induced by an uterotonic herb (Ligusticum chuanxiong)". Livestock Science 163: 159–164. doi:10.1016/j.livsci.2014.02.012. ISSN 1871-1413. 



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